Antibiotic Resistance genes dynamics and operation performance of AnMBRs under Amoxicillin/Flucloxacillin Exposure
Kamal, A., Tarek, A., Safwat, S., Saleh, M., Elawwad, A. (2025). Antibiotic Resistance genes dynamics and operation performance of AnMBRs under Amoxicillin/Flucloxacillin Exposure. EKB Journal Management System, 68(6), 235-246. doi: 10.21608/ejchem.2024.307488.10086
Ahmed Kamal; Amany Tarek; Safwat M. Safwat; Mahmoud Saleh; Abdelsalam Elawwad. "Antibiotic Resistance genes dynamics and operation performance of AnMBRs under Amoxicillin/Flucloxacillin Exposure". EKB Journal Management System, 68, 6, 2025, 235-246. doi: 10.21608/ejchem.2024.307488.10086
Kamal, A., Tarek, A., Safwat, S., Saleh, M., Elawwad, A. (2025). 'Antibiotic Resistance genes dynamics and operation performance of AnMBRs under Amoxicillin/Flucloxacillin Exposure', EKB Journal Management System, 68(6), pp. 235-246. doi: 10.21608/ejchem.2024.307488.10086
Kamal, A., Tarek, A., Safwat, S., Saleh, M., Elawwad, A. Antibiotic Resistance genes dynamics and operation performance of AnMBRs under Amoxicillin/Flucloxacillin Exposure. EKB Journal Management System, 2025; 68(6): 235-246. doi: 10.21608/ejchem.2024.307488.10086

Antibiotic Resistance genes dynamics and operation performance of AnMBRs under Amoxicillin/Flucloxacillin Exposure

Egyptian Journal of Chemistry
Volume 68, Issue 6, June 2025, Page 235-246  XML PDF (589.02 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.307488.10086
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Authors
Ahmed Kamal1; Amany Tarek1; Safwat M. Safwatorcid 1; Mahmoud Saleh email orcid 2; Abdelsalam Elawwad1
1Sanitary and Environmental Engineering Division, Public Works Department, Faculty of Engineering, Cairo University, Giza 12613, Egypt
2Faculty of Science, Cairo University
Abstract
Anaerobic membrane bioreactors (AnMBRs) offer a promising solution for wastewater treatment, combining anaerobic digestion with membrane filtration to efficiently remove pollutants and mitigate the spread of antibiotic resistance genes (ARGs). The impact of antibiotic mixtures on AnMBR performance and ARG profiles remains crucial to investigate due to their prevalence in various environments. This study examined the effects of an amoxicillin and flucloxacillin mixture on key operational parameters in an AnMBR system. The AnMBR demonstrated resilience to the antibiotic mixture, maintaining a high average chemical oxygen demand (COD) removal efficiency (91 ± 4.5%) and stable biogas production (713 ± 150 L/d) even at elevated antibiotic concentrations (250 μg/L). However, antibiotic presence significantly influenced ARG profiles within the biomass and effluent, highlighting the complex interplay between antibiotic exposure and resistance gene dynamics. These findings emphasize the importance of understanding and optimizing AnMBR performance under antibiotic pressure to mitigate the spread of antibiotic resistance while ensuring effective wastewater treatment and resource recovery.
Keywords
Antibiotic resistance genes (ARGs); Anaerobic membrane bioreactors (AnMBRs); Wastewater treatment; Amoxicillin; Flucloxacillin; Antibiotic mixture
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