The Significance of Interleukin 6 in Predicting Severity of Covid -19 Infection in Egyptian Patients | ||||
| Sohag Medical Journal | ||||
| Volume 29, Issue 1, 2025, Page 1-12 PDF (720.32 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/smj.2024.326114.1497 | ||||
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| Authors | ||||
Ahmed Elmetwally Ahmed  1; Nanees Ahmed Adel2; Mohamed Fayez Abdel Kader3; George Safwat Riad2
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| 1Gastroenterology ,Hepatology and Internal Medicine Department, Ain Shams Univeristy | ||||
| 2Gastroenterology ,Hepatology and Internal Medicine Department, Ain Shams Univeristy | ||||
| 3Abbasia Fever Hospital | ||||
| Abstract | ||||
| Background: Covid-19 infection is a highly infectious illness with high mortality especially among elderly patients with chronic illnesses . During the pandemic of Covid-19 , it is necessary to find a screening method to predict the patients at high risk for developing severe immortal disease . increased interleukin-6 (IL-6) is a key factor contributing to the cytokine storm syndrome involved in clinical manifestations of Covid-19. Aim of the work: to determine the significance of Interleukin- 6 as a predictive factor of Hypoxemia and the severity of Covid-19 infection . Subjects and Methods: Case - Control study was done at Abassia Fever hospital and Ain Shams University Isolation Hospitals on 75 persons (50 patients with different grades of severity for Covid-19 disease and 25 controls) during 6 months duration from September 2021 to March 2022 . Results: we found a statistically significant difference as regard serum IL-6 between critically severe , mild and control groups with more increased levels of IL-6 between died patients than survived patients . Conclusion: Neutrophil-Lymphocyte Ratio , CRP , ESR , Ferritin and Albumin were associated with increased disease severity and worse clinical outcome but IL-6 was found to be better than them in predicting disease severity . the level of IL-6 > 12.6 pg/mL at the initial presentation had excellent sensitivity and specificity in predicting the development of hypoxia demanding hospitalization . Further larger studies are needed to predict the significance of IL-6 as an effective screening method for the severe Covid-19 disease . | ||||
| Keywords | ||||
| Keyword: Covid-19; Hypoxemia; Interleukin 6 | ||||
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