The role of new potential biomarker for medicolegal aging of wounds
Elroby, F., Ghaleb, S., Abdelsattar, H., Nagdi, G., Ahmad, M. (2024). The role of new potential biomarker for medicolegal aging of wounds. EKB Journal Management System, 5(4), 30-43. doi: 10.21608/ejmr.2024.262954.1528
Fadwa Aly Elroby; Sherein S Ghaleb; Hossam A Abdelsattar; Gehad Ali Nagdi; Manar A Ahmad. "The role of new potential biomarker for medicolegal aging of wounds". EKB Journal Management System, 5, 4, 2024, 30-43. doi: 10.21608/ejmr.2024.262954.1528
Elroby, F., Ghaleb, S., Abdelsattar, H., Nagdi, G., Ahmad, M. (2024). 'The role of new potential biomarker for medicolegal aging of wounds', EKB Journal Management System, 5(4), pp. 30-43. doi: 10.21608/ejmr.2024.262954.1528
Elroby, F., Ghaleb, S., Abdelsattar, H., Nagdi, G., Ahmad, M. The role of new potential biomarker for medicolegal aging of wounds. EKB Journal Management System, 2024; 5(4): 30-43. doi: 10.21608/ejmr.2024.262954.1528

The role of new potential biomarker for medicolegal aging of wounds

Egyptian Journal of Medical Research
Volume 5, Issue 4, October 2024, Pages 30-43    PDF (967.76 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.262954.1528
Authors
Fadwa Aly Elroby1; Sherein S Ghaleb1; Hossam A Abdelsattar2; Gehad Ali Nagdi* 1; Manar A Ahmad1
1Forensic medicine and clinical toxicology department, Faculty of medicine, Beni-Suef University, Beni-Suef , Egypt
2orthopedic surgery department, Faculty of medicine, Beni-suef University, Beni-suef
Abstract
Background: Estimating the age of a wound is crucial in the realm of forensic medicine. Determining the age and liveliness of a wound is essential for the appropriate handling of legal procedures. Objective: to evaluate the myostatin marker's usefulness in determining the age of medicolegal wounds. Methods: This cross-sectional investigation on the ante-mortem aging of surgically non-complicated wounds was conducted at the general and orthopedic surgery departments of Beni Suef University Hospital. 56 participants were divided evenly into two equal groups: Group B involved muscle injuries while Group A involved bone injuries. Each participant had blood drawn nine times following surgery: before and after zero (pre-operative), twenty-four hours, thirty-six hours, forty-eight hours, seventy-two hours, eighty-four hours, ninety-six hours, ninety-six hours, and one hundred and sixty hours (post-operative).  Results: Over the course of the five days, there were notable (P < 0.001) increases in myostatin levels, peaking 36 hours after the wound (3.73±0.42) as opposed to the bone injury group's zero time (2.07±0.76). Additionally, across the course of the five days, there were notable (P < 0.001) increases, with the muscle injury group's peak being reached 24 hours after the wounding (1.94±0.71) as opposed to the zero time (1.45±0.40). Conclusion: myostatin can be used to assess medicolegal wound age in bone and muscle injuries.
Keywords
Wound aging; Myostatin; Bone; Muscle
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