Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients | ||||
| Egyptian Journal of Anaesthesia | ||||
| Volume 36, Issue 1, January 2020, Page 118-125 PDF (1.67 MB) | ||||
| DOI: TEJA-2020-0053 | ||||
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| Authors | ||||
| Ahmed M. El Said; Akram M. Fayed; Ehab M. El-Reweny | ||||
| Abstract | ||||
| Background Outcome prediction in septic shock is a prime concern as it may facilitate more aggressive interventions to be made at appropriate time to reduce costs and mortality. We evaluated combining complete blood count (CBC) indices [red cell distribution width (RDW), mean platelet volume (MPV), neutrophil–lymphocyte ratio (NLR)] for septic shock early prognostication in comparison to presepsin. Methods Sixty adult intensive care unit (ICU) patients with septic shock according to Sepsis-3 were enrolled. Blood assembling on admission and day 3 to determine presepsin level, and CBC indices which were interpreted as RDW, MPV, and NLR. Patients were sorted into survivors (Group I) and non-survivors (Group II). Results Presepsin in non-survivors was higher significantly on admission and day 3 ( < 0.00 <0.00 respectively). RDW in non-survivors was higher significantly on admission and day 3 ( = 0.0 0.00 respectively). MPV in non-survivors was higher significantly on admission and day 3 ( = 0.030, 0.00 respectively). NLR in non-survivors was higher significantly on admission and day 3 ( = 0.00 <0.00 respectively). The calculated AUCs were 0.890 ( < 0.00 for presepsin, with 9% sensitivity, 83% specificity, and 88% accuracy, and 0.84 ( < 0.00 for CBC indices combination, with 89% sensitivity, 85% specificity, and 86% accuracy. Significant positive correlation was found between presepsin and CBC indices combination ( = 0.4, = 0.00. Conclusion Combination of RDW, MPV, and NLR could be integrated into septic shock early prognostication tools with sensitivity, specificity, and accuracy similar to presepsin. | ||||
| Keywords | ||||
| Septic shock; presepsin; red cell distribution width (RDW); Mean Platelet Volume (MPV); neutrophil–lymphocyte ratio (NLR); prognosis | ||||
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