Early prediction of acute kidney injury with cell cycle arrest biomarkers using plethesmography directed fluid management in major abdominal surgery
Mahran, M., Sabry Ahmed, A., Aly Mohamed, A., Khalifa Elsayed, A. (2022). Early prediction of acute kidney injury with cell cycle arrest biomarkers using plethesmography directed fluid management in major abdominal surgery. EKB Journal Management System, 38(1), 415-422. doi: TEJA-2022-0105
Marwa Medhat Ahmed Mahran; Amal Mohamed Sabry Ahmed; Ahmed Youssef Aly Mohamed; Ayman Fathy Khalifa Elsayed. "Early prediction of acute kidney injury with cell cycle arrest biomarkers using plethesmography directed fluid management in major abdominal surgery". EKB Journal Management System, 38, 1, 2022, 415-422. doi: TEJA-2022-0105
Mahran, M., Sabry Ahmed, A., Aly Mohamed, A., Khalifa Elsayed, A. (2022). 'Early prediction of acute kidney injury with cell cycle arrest biomarkers using plethesmography directed fluid management in major abdominal surgery', EKB Journal Management System, 38(1), pp. 415-422. doi: TEJA-2022-0105
Mahran, M., Sabry Ahmed, A., Aly Mohamed, A., Khalifa Elsayed, A. Early prediction of acute kidney injury with cell cycle arrest biomarkers using plethesmography directed fluid management in major abdominal surgery. EKB Journal Management System, 2022; 38(1): 415-422. doi: TEJA-2022-0105

Early prediction of acute kidney injury with cell cycle arrest biomarkers using plethesmography directed fluid management in major abdominal surgery

Egyptian Journal of Anaesthesia
Volume 38, Issue 1, December 2022, Page 415-422  XML PDF (3.63 MB)
DOI: TEJA-2022-0105
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Authors
Marwa Medhat Ahmed Mahran; Amal Mohamed Sabry Ahmed; Ahmed Youssef Aly Mohamed; Ayman Fathy Khalifa Elsayed
Abstract
Background
Acute kidney injury (AKI) is a known complication after major abdominal surgery. Use of the usual functional AKI biomarkers for detection shows delayed results, and so, the use of cell cycle arrest biomarker was proposed.
Purpose
The aim of the present study was to assess the arrest biomarker as an early tool for AKI prediction in major abdominal surgery.
Methods
After receiving approval from the Ethics Committee and taking informed written consent, a prospective randomized study was conducted. Forty adult patients were scheduled for major abdominal surgery. Patients were randomly categorized using closed-envelope technique into two equal groups (25 patients each): the control group (20 patients) with intraoperative standard fluid therapy and the goal-directed fluid therapy (GDT) (20 patients) using plethysmography. Urinary cycle arrest biomarkers were measured at 4 and 12 h after ICU admission.
Results
The mean value of the arrest biomarkers showed a significant increase in the control group only at 4 h period ( = 0.017). Moreover, there was a statistically significant increase in the number of positive patients in the control group at 4 h period only ( = 0.044). Urine arrest biomarkers were higher in AKI patients than in the non-AKI ones at 4 h ( = 0.003) and 12 h ( = 0.004). The arrest biomarker AUROC values at 4 and 12 h were 0.887 and 0.875, respectively.
Conclusion
From these results, we concluded that cell cycle arrest biomarkers can predict AKI after major abdominal surgery. In addition, AKI incidence showed no difference between the control group and the GDT group.
Keywords
prediction; cell cycle arrest biomarkers; Acute kidney injury; major abdominal surgery; plethysmography
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