Nebulized vs. oral midazolam as a sedative premedication in pediatric anesthesia: A randomized controlled double-blinded study | ||||
| Egyptian Journal of Anaesthesia | ||||
| Volume 38, Issue 1, December 2022, Page 476-482 PDF (699.24 K) | ||||
| DOI: TEJA-2022-0122 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Sherif Mohamed Soaida; Mohamed EL-Saied Hafez; Karim Kamal Girgis; Mohamed Mahmoud Marie; Mohamed Ahmed Selim | ||||
| Abstract | ||||
| Objective This study was carried out to compare different routes of midazolam administration (nebulized vs. oral) to achieve a satisfactory level of sedation, RAMSAY Sedation Score (RSS) of 4, within 30 minutes of midazolam administration in pediatric operative patients. Methods After approval of the ethical committee in Kasr Al-ainy university hospital and obtaining written consent from parents/legal guardians; Seventy-two pediatric patients scheduled for general and urological surgical operations under general anesthesia were included in this randomized double-blinded study. Patients were randomly assigned into one of the two equal groups. Group N: 36 children received nebulized midazolam 0.2 mg/kg in 3 ml normal saline plus 5 ml clear juice 30 min before undergoing general anesthesia (GA). Group O: 36 children received oral midazolam 0.5 mg/kg in 5 ml clear juice plus nebulizer of 3 ml normal saline 30 min before undergoing general anesthesia. Results We found no statistical difference between nebulized and oral midazolam regarding drug acceptance, peri-operative (sedation scores, hemodynamics, and side effects); P-value >0.05 for all values. Conclusion Nebulized midazolam is a good alternative to oral midazolam as a sedative premedication in pediatrics. | ||||
| Keywords | ||||
| Nebulized; midazolam; RAMSAY; Sedation; Premedication; Pediatric | ||||
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