Deep neuromuscular blocking and sugammadex reversing-drug is an efficient strategy permitting successful laparoscopic surgery under low insufflation pressure: Prospective multicenter study
Shehab, H., Mostafa, I., Salman, S. (2023). Deep neuromuscular blocking and sugammadex reversing-drug is an efficient strategy permitting successful laparoscopic surgery under low insufflation pressure: Prospective multicenter study. EKB Journal Management System, 39(1), 883-893. doi: TEJA-2023-0236
Hany A. Shehab; Ibrahim E.M. Mostafa; Samar A. Salman. "Deep neuromuscular blocking and sugammadex reversing-drug is an efficient strategy permitting successful laparoscopic surgery under low insufflation pressure: Prospective multicenter study". EKB Journal Management System, 39, 1, 2023, 883-893. doi: TEJA-2023-0236
Shehab, H., Mostafa, I., Salman, S. (2023). 'Deep neuromuscular blocking and sugammadex reversing-drug is an efficient strategy permitting successful laparoscopic surgery under low insufflation pressure: Prospective multicenter study', EKB Journal Management System, 39(1), pp. 883-893. doi: TEJA-2023-0236
Shehab, H., Mostafa, I., Salman, S. Deep neuromuscular blocking and sugammadex reversing-drug is an efficient strategy permitting successful laparoscopic surgery under low insufflation pressure: Prospective multicenter study. EKB Journal Management System, 2023; 39(1): 883-893. doi: TEJA-2023-0236

Deep neuromuscular blocking and sugammadex reversing-drug is an efficient strategy permitting successful laparoscopic surgery under low insufflation pressure: Prospective multicenter study

Egyptian Journal of Anaesthesia
Volume 39, Issue 1, December 2023, Page 883-893  XML PDF (2.12 MB)
DOI: TEJA-2023-0236
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Authors
Hany A. Shehab; Ibrahim E.M. Mostafa; Samar A. Salman
Abstract
Objectives
To compare using deep neuromuscular blockade during low abdominal insufflation pressure (DNMB/LAIP;  = 67) to conventional blockade and pressure (CNMB/CAIP;  = 68) for laparoscopic cholecystectomy and to evaluate the speed and efficacy of NMB recovery using sugammadex (SGX) as assessed by the Postoperative Quality Recovery Scale.
Patients & Methods
Rocuronium initiation and maintenance doses were 0.6 and 0.15 mg/Kg, respectively, and neostigmine or SGX was used as reverse agent for CNMB and DNMB, respectively. Abdominal insufflation was terminated at 15 and 8-mmHg, for CAIP and LAIP, respectively. The study outcome is the surgical feasibility under DNMB/LAIP, as judged by the frequency of shift-to-CAIP, surgical field visibility and operative time.
Results
The frequency of shift-to-CAIP was 2.9% due to surgeons’ inconvenience of LAIP. DNMB allowed significant control of intraoperative (IO) hemodynamic response to surgical manipulations. SGX allowed 3.2 times faster NMB-reversal with significantly higher percentages of patients returned to baseline physiologic statuses. The percentage of patients free of pain and nausea was significantly higher after DNMB/LAIP. At hospital discharge and day-7 PO, 86.6% and 98.5% of patients regained normalcy of their overall perspectives after DNMB/LAIP with a significant difference than after CNMB/CIAP. At 2-week PO, the frequency of shoulder-tip pain (STP) was significantly lower and surgeons’ satisfaction rate was significantly with DNMB/LAIP.
Conclusion
Laparoscopic cholecystectomy under DNMB/LAIP procedure is feasible and safe with lower incidence and severity of STP and high surgeons’ satisfaction. Sugammadex hastened the recovery of DNMB 3.2 times that of neostigmine-induced recovery of CNMB. Registration NO: RC.3.9.2023
Keywords
Deep neuromuscular blockade; Sugammadex; low abdominal insufflation pressure; laparoscopic surgery; Postoperative quality recovery scale; shoulder-tip pain
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