The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study
El-Deeb, A., El-Morsy, G., Ghanem, A., Elsharkawy, A., Elmetwally, A. (2013). The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study. EKB Journal Management System, 29(3), 225-230. doi: 10.1016/j.egja.2013.02.005
Alaa El-Deeb; Gamal Z. El-Morsy; Abdel Aziz A. Ghanem; Ashraf A. Elsharkawy; Ashraf S. Elmetwally. "The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study". EKB Journal Management System, 29, 3, 2013, 225-230. doi: 10.1016/j.egja.2013.02.005
El-Deeb, A., El-Morsy, G., Ghanem, A., Elsharkawy, A., Elmetwally, A. (2013). 'The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study', EKB Journal Management System, 29(3), pp. 225-230. doi: 10.1016/j.egja.2013.02.005
El-Deeb, A., El-Morsy, G., Ghanem, A., Elsharkawy, A., Elmetwally, A. The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study. EKB Journal Management System, 2013; 29(3): 225-230. doi: 10.1016/j.egja.2013.02.005

The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study

Egyptian Journal of Anaesthesia
Volume 29, Issue 3, July 2013, Pages 225-230    PDF (630.6 K)
DOI: 10.1016/j.egja.2013.02.005
Authors
Alaa El-Deeb; Gamal Z. El-Morsy; Abdel Aziz A. Ghanem; Ashraf A. Elsharkawy; Ashraf S. Elmetwally
Abstract
Background
Lidocaine attenuates the stress response to surgery when given intravenously. This study investigated the effect of perioperative lidocaine infusion on hormonal responses, bowel function and hospital stay after major abdominal surgeries in pediatrics.
Methods
After obtaining the Research Ethics Board (REB) approval and written informed parental consent, 80 pediatric patients aged 1–6 years, ASA II, III scheduled for abdominal major surgery were randomly allocated into two groups, each of forty children. Twenty minutes before induction, children in placebo group received saline in a rate of 1.5 ml/kg/h and those in lidocaine group received lidocaine 1.5 mg/kg intravenously then infusion of 1.5 mg/kg/h up to 6 h postoperatively. Length of hospital stay and return of bowel function were reported. Plasma cortisol was recorded at baseline, 10 min after continuous infusion, 5 min after intubation and 10 min after extubation. Serum lidocaine concentrations were recorded 10 min after start of infusion, 10 min and 4 h after extubation.
Results
Patients in placebo group showed significant higher plasma cortisol concentrations ( = 0.001) in response to induction of anesthesia and extended postoperatively when compared to lidocaine group.
Conclusion
Intravenous lidocaine infusion, started preoperatively and continued for 6 h postoperatively, attenuated stress response to major abdominal pediatric surgery. It also decreased hospital stay, opioid requirement and hastened return of bowel function.
Keywords
Lidocaine; Abdominal pediatric surgery; hospital stay
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