Ketamine/propofol versus fentanyl/propofol for sedating obese patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) | ||||
| Egyptian Journal of Anaesthesia | ||||
| Volume 29, Issue 3, July 2013, Page 207-211 PDF (362.07 K) | ||||
| DOI: 10.1016/j.egja.2013.02.009 | ||||
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| Authors | ||||
| Riham Hasanein; Wael El-Sayed | ||||
| Abstract | ||||
| Objective This study was conducted to compare two techniques of sedation for obese patients undergoing ERCP, using either ketofol or fentanyl–propofol as regards propofol consumption, recovery time, patients’ satisfaction, and sedation-related adverse events. Materials and methods Two hundred obese patients were randomly allocated to one of two groups; ketamine/propofol (ketofol) group KP ( = 100) or fentanyl/propofol group FP ( = 100). The level of sedation was adjusted to achieve a Ramsay Sedation Scale (RSS) score of 5. Results Total dose of propofol consumed was significantly higher in group FP compared with group KP (97.08 ± 23.31 mg and 57.71 ± 16.97) mg. Recovery time was slightly longer in group KP compared with group FP (11.19 ± 2.59 min and 9.43 ± 1.23 min, respectively), time needed to achieve Aldrete Recovery Scale Score of 9 was comparable in both groups, and sedation-related side effects as hypotension, bradycardia, apnea, and reduction of SpO were more significant in the FP group. In conclusion Ketamine/propofol combination 1:4 provided better sedation quality than fentanyl/propofol combination with less side effects and can be safely used for sedating obese patients undergoing ERCP. | ||||
| Keywords | ||||
| Ketamine; propofol; Sedation; ERCP; Obesity | ||||
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