Effect of intranasal dexmedetomidine or intranasal midazolam on prevention of emergence agitation in pediatric strabismus surgery: A randomized controlled study
Abdelaziz, H., Bakr, R., Kasem, A. (2016). Effect of intranasal dexmedetomidine or intranasal midazolam on prevention of emergence agitation in pediatric strabismus surgery: A randomized controlled study. EKB Journal Management System, 32(3), 285-291. doi: 10.1016/j.egja.2015.11.009
Hesham Mohamed Mamdouh Abdelaziz; Radwa Hamdi Bakr; Ayman A. Kasem. "Effect of intranasal dexmedetomidine or intranasal midazolam on prevention of emergence agitation in pediatric strabismus surgery: A randomized controlled study". EKB Journal Management System, 32, 3, 2016, 285-291. doi: 10.1016/j.egja.2015.11.009
Abdelaziz, H., Bakr, R., Kasem, A. (2016). 'Effect of intranasal dexmedetomidine or intranasal midazolam on prevention of emergence agitation in pediatric strabismus surgery: A randomized controlled study', EKB Journal Management System, 32(3), pp. 285-291. doi: 10.1016/j.egja.2015.11.009
Abdelaziz, H., Bakr, R., Kasem, A. Effect of intranasal dexmedetomidine or intranasal midazolam on prevention of emergence agitation in pediatric strabismus surgery: A randomized controlled study. EKB Journal Management System, 2016; 32(3): 285-291. doi: 10.1016/j.egja.2015.11.009

Effect of intranasal dexmedetomidine or intranasal midazolam on prevention of emergence agitation in pediatric strabismus surgery: A randomized controlled study

Egyptian Journal of Anaesthesia
Volume 32, Issue 3, July 2016, Page 285-291  XML PDF (427.13 K)
DOI: 10.1016/j.egja.2015.11.009
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Authors
Hesham Mohamed Mamdouh Abdelaziz; Radwa Hamdi Bakr; Ayman A. Kasem
Abstract
Background
Following strabismus surgery under sevoflurane anesthesia children often experience emergence agitation (EA) and postoperative vomiting (POV). This study compared the effects of premedication with intranasal dexmedetomidine, midazolam, and placebo on postoperative EA and POV.
Methods
105 children (aged 1–7 years) undergoing elective strabismus surgery under sevoflurane anesthesia were randomly assigned to one of three groups ( = 35 each). Preoperatively, group D received intranasal (IN) dexmedetomidine (1 μg/kg), group M received IN midazolam (0.1 mg/kg), and group C received (1 ml) IN normal saline. Agitation scores (Pediatric Anesthesia Emergence Delirium [PAED] scale) and POV were assessed in post-anesthesia care unit (PACU). The incidence of intraoperative Oculocardiac Reflex OCR events, Time to spontaneous eye opening, Postoperative pain score, total consumption of rescue analgesia and time to discharge from PACU were also assessed.
Results
98 children completed the study. Incidence of agitation (defined as PAED score ⩾ 10) was significantly higher in the control group and the midazolam group than in the dexmedetomidine group ( = 0.014), and the number of patients who developed severe agitation requiring fentanyl (PAED score ⩾ 15) was also higher in the control group ( = 0.042).
Conclusion
Administration of intranasal dexmedetomidine to children undergoing strabismus surgery under sevoflurane anesthesia resulted in a reduced incidence of EA compared with intranasal midazolam or placebo. The incidence of POV and intraoperative OCR was also significantly lower with dexmedetomidine.
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