Beta Endorphins, Interleukin 1 and Interleukin 38 in Covid Patients Associated with Neuropsychological Manifestations | ||||
| SECI Oncology Journal | ||||
| Article 1, Volume 12, Issue 4, October 2024, Page 324-331 | ||||
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| Abstract | ||||
| Background: Coronavirus was identified as a cause of a worldwide epidemic which led to millions of deaths globally. Although most COVID-19 patients have initially complained of respiratory insufficiency, the presence of neuropsychiatric manifestations is also reported frequently. These neuropsychiatric complications have emerged as a potential indicator of worsened clinical outcomes and poor prognosis [1]. This study aimed to detect the levels of βeta endorphins, interleukin 1, and interleukin 38 in the serum of COVID-19 patients and their relation to the development of neuropsychiatric symptoms. Methods: a case-control study conducted on 50 COVID-19 patients and 40 healthy controls in the clinical pathology department, South Egypt Cancer Institute, Assiut University. Patients with Other respiratory diseases and previous neuropsychiatric disorders were excluded. All patients and control are assessed by using psychometric tests for anxiety and depression (Hamilton depression and anxiety). Serum interleukin 1 beta, interleukin 38 and Beta- endorphin were measured by ELISA. Results: Our study showed that IL1 and β endorphins were higher in the serum of COVID patients as compared to controls. As for IL38 and β endorphins, COVID cases without neuropsychiatric manifestations had significantly higher IL38 levels and β endorphins than those with neuropsychiatric manifestations. Conclusion: Neuropsychological assessment suggests a higher incidence of anxiety/depression among COVID‐19 patients. This study indicates that serum IL-1, IL‐38 & β-Endorphins levels were affected by COVID‐19 infection, and may be involved in developing neuropsychiatric complications and could help in targeting a therapy toward this complication. | ||||
| Keywords | ||||
| Covid 19; neuropsychiatric disorders- interleukin 1- intelekin38; beta endorphins | ||||
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