IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity
Fahmy, Y., El-Korashi, L., Attia, H., Attia, O., Behiry, A., El-sayed, H. (2025). IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity. EKB Journal Management System, 34(1), 119-130. doi: 10.21608/ejmm.2024.326786.1354
Yasmin A. Fahmy; Lobna A. El-Korashi; Haitham M. Attia; Osama Attia; Ahmed S. Behiry; Hend A. El-sayed. "IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity". EKB Journal Management System, 34, 1, 2025, 119-130. doi: 10.21608/ejmm.2024.326786.1354
Fahmy, Y., El-Korashi, L., Attia, H., Attia, O., Behiry, A., El-sayed, H. (2025). 'IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity', EKB Journal Management System, 34(1), pp. 119-130. doi: 10.21608/ejmm.2024.326786.1354
Fahmy, Y., El-Korashi, L., Attia, H., Attia, O., Behiry, A., El-sayed, H. IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity. EKB Journal Management System, 2025; 34(1): 119-130. doi: 10.21608/ejmm.2024.326786.1354

IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity

Egyptian Journal of Medical Microbiology
Article 14, Volume 34, Issue 1, January 2025, Page 119-130  XML PDF (753.52 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2024.326786.1354
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Authors
Yasmin A. Fahmy email 1; Lobna A. El-Korashi1; Haitham M. Attia2; Osama Attia3; Ahmed S. Behiry4; Hend A. El-sayed1
1Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2ENT Specialist, Al-Ahrar Teaching Hospital, Zagazig, Egypt
3Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: The inflammatory role of some cytokines in allergic rhinitis (AR) is not yet well illustrated. Understanding its role may form a target for novel therapeutics. Objectives: To assess the levels of IL-17, TNF-α, IL-8 and IL-22 in sera of AR patients and to correlate their levels with disease severity. Methodology: This case-control study included 26 AR patients and 26 healthy controls. Blood samples of all participants were tested for levels of total IgE, IL-17, TNF-α, IL-8 and IL-22 serum using ELISA method. Skin prick test (SPT) and Specific IgE (sIgE) for aeroallergens were done by immunoblot assay for all AR patients.  Results: AR patients possessed higher serum levels of IL-17, IL22, TNF-α and IL-8 (P= 0.006, <0.00, 0.013 and<0.001 respectively) compared to the control group. There was a statistically significant relation between disease severity (evaluated through visual analogue score (VAS)) and TNF-α& IL-22 serum levels (P= 0.031& <0.001 respectively). Conclusion: IL-17, IL-22, TNF-α and IL-8 promote the inflammatory response in AR patients. TNF-α and IL-22 were directly correlated with AR severity.
Keywords
Allergy; Allergen; Interleukin; Cytokine; Chemokine
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