IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity | ||
Egyptian Journal of Medical Microbiology | ||
Article 14, Volume 34, Issue 1, January 2025, Pages 119-130 PDF (753.52 K) | ||
Document Type: New and original researches in the field of Microbiology. | ||
DOI: 10.21608/ejmm.2024.326786.1354 | ||
Authors | ||
Yasmin A. Fahmy* 1; Lobna A. El-Korashi1; Haitham M. Attia2; Osama Attia3; Ahmed S. Behiry4; Hend A. El-sayed1 | ||
1Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
2ENT Specialist, Al-Ahrar Teaching Hospital, Zagazig, Egypt | ||
3Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
4Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
Abstract | ||
Background: The inflammatory role of some cytokines in allergic rhinitis (AR) is not yet well illustrated. Understanding its role may form a target for novel therapeutics. Objectives: To assess the levels of IL-17, TNF-α, IL-8 and IL-22 in sera of AR patients and to correlate their levels with disease severity. Methodology: This case-control study included 26 AR patients and 26 healthy controls. Blood samples of all participants were tested for levels of total IgE, IL-17, TNF-α, IL-8 and IL-22 serum using ELISA method. Skin prick test (SPT) and Specific IgE (sIgE) for aeroallergens were done by immunoblot assay for all AR patients. Results: AR patients possessed higher serum levels of IL-17, IL22, TNF-α and IL-8 (P= 0.006, <0.00, 0.013 and<0.001 respectively) compared to the control group. There was a statistically significant relation between disease severity (evaluated through visual analogue score (VAS)) and TNF-α& IL-22 serum levels (P= 0.031& <0.001 respectively). Conclusion: IL-17, IL-22, TNF-α and IL-8 promote the inflammatory response in AR patients. TNF-α and IL-22 were directly correlated with AR severity. | ||
Keywords | ||
Allergy; Allergen; Interleukin; Cytokine; Chemokine | ||
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