Comparative Study Between Intratympanic Methylprednisolone Injection versus Dexamethasone for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss
Ahmed Abd Elmonem, M., Ismail, A., Youssef, R., Youssef, R. (2024). Comparative Study Between Intratympanic Methylprednisolone Injection versus Dexamethasone for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss. EKB Journal Management System, 5(4), 100-116. doi: 10.21608/ejmr.2023.228377.1442
Mohamed Sherif Ahmed Abd Elmonem; Ahmed Hamdy Ismail; Ragaey Youssef; Rabie Sayed Youssef. "Comparative Study Between Intratympanic Methylprednisolone Injection versus Dexamethasone for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss". EKB Journal Management System, 5, 4, 2024, 100-116. doi: 10.21608/ejmr.2023.228377.1442
Ahmed Abd Elmonem, M., Ismail, A., Youssef, R., Youssef, R. (2024). 'Comparative Study Between Intratympanic Methylprednisolone Injection versus Dexamethasone for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss', EKB Journal Management System, 5(4), pp. 100-116. doi: 10.21608/ejmr.2023.228377.1442
Ahmed Abd Elmonem, M., Ismail, A., Youssef, R., Youssef, R. Comparative Study Between Intratympanic Methylprednisolone Injection versus Dexamethasone for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss. EKB Journal Management System, 2024; 5(4): 100-116. doi: 10.21608/ejmr.2023.228377.1442

Comparative Study Between Intratympanic Methylprednisolone Injection versus Dexamethasone for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss

Egyptian Journal of Medical Research
Volume 5, Issue 4, October 2024, Pages 100-116    PDF (536.72 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2023.228377.1442
Authors
Mohamed Sherif Ahmed Abd Elmonem1; Ahmed Hamdy Ismail* 1; Ragaey Youssef2; Rabie Sayed Youssef1
1Otorhinolaryngology department, Faculty of Medicine, Beni-Suef University, Egypt
2Audio-Vestibular Medicine department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
Background: Idiopathic sudden sensorineural hearing loss (ISSHL) continues to be a medical mystery, both in terms of its cause and its therapy. Corticosteroids are supposed to aid ISSHL healing because of their anti-inflammatory effects. In this study, we compared the effectiveness of two steroid treatments for ISSHL: methylprednisolone (40 mg/mg) and dexamethasone (24 mg/ml). Methods: In a randomized, interventional study, we recruited 40 patients with ISSHL. Patients were randomly allocated to group (A) received injection of 1 ml Dexamethasone (24mg/ml) in the middle ear cavity and group (B) Injection of 1ml of Methylprednisolone (40 mg/ml) in the middle ear cavity, every patient in each group was injected 5 times in consecutive days and PTA and tympanometry done 3days,5 days, and 6weeks postoperatively. Results: There was statistically insignificant higher complete and partial recovery in Methylprednisolone than Dexamethasone groups. In methylprednisolone group (17.4%) showed partial recovery compared to (16%) in dexamethasone group. Also, (21.7%) in methylprednisolone group showed complete recovery compared to (12%) in dexamethasone group. The mean speech discrimination after injection was 74.3%±19.3% in methylprednisolone group and 69.6%±31.6% in dexamethasone group. There was insignificant improvement in speech discrimination in both groups however, the absolute mean difference was higher in Methylprednisolone than Dexamethasone group.  Conclusions: With a poor likelihood of recovery, idiopathic sudden sensorineural hearing loss continues to be a difficult clinical issue. Intratympanic steroid injection, however, is a comparatively efficient, secure, and well-tolerated method for the treatment of ISSHL. Results related to hearing loss strongly recommend using methylprednisolone intratympanic injection rather than dexamethasone.
Keywords
ISSHL; Hearing Loss; Dexamethasone; Methylprednisolone
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