Neurological manifestations of inflammatory multisystem syndrome temporally associated with COVID 19 in Pediatric intensive care unit
Abdel Tawab, M., Ali Abbas, A., Morgan, D., Ibrahim, A. (2024). Neurological manifestations of inflammatory multisystem syndrome temporally associated with COVID 19 in Pediatric intensive care unit. EKB Journal Management System, 5(4), 117-137. doi: 10.21608/ejmr.2024.308980.1657
Mohamed Adel Abdel Tawab; Ahmed Samir Ali Abbas; Dalia Saber Morgan; Asmaa Fathelbab Ibrahim. "Neurological manifestations of inflammatory multisystem syndrome temporally associated with COVID 19 in Pediatric intensive care unit". EKB Journal Management System, 5, 4, 2024, 117-137. doi: 10.21608/ejmr.2024.308980.1657
Abdel Tawab, M., Ali Abbas, A., Morgan, D., Ibrahim, A. (2024). 'Neurological manifestations of inflammatory multisystem syndrome temporally associated with COVID 19 in Pediatric intensive care unit', EKB Journal Management System, 5(4), pp. 117-137. doi: 10.21608/ejmr.2024.308980.1657
Abdel Tawab, M., Ali Abbas, A., Morgan, D., Ibrahim, A. Neurological manifestations of inflammatory multisystem syndrome temporally associated with COVID 19 in Pediatric intensive care unit. EKB Journal Management System, 2024; 5(4): 117-137. doi: 10.21608/ejmr.2024.308980.1657

Neurological manifestations of inflammatory multisystem syndrome temporally associated with COVID 19 in Pediatric intensive care unit

Egyptian Journal of Medical Research
Volume 5, Issue 4, October 2024, Page 117-137  XML PDF (764.63 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.308980.1657
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Authors
Mohamed Adel Abdel Tawab1; Ahmed Samir Ali Abbas email orcid 1; Dalia Saber Morgan1; Asmaa Fathelbab Ibrahim2
1Pediatrics department, Faculty of Medicine, Beni-Suef University
2Clinical and chemical pathology, Faculty of Medicine, Beni-Suef University
Abstract
Background: Patients under the age of 21 who present with a high temperature, inflammatory markers in the lab, and a severe illness that necessitates hospitalization due to involvement of multiple systems (such as the cardiovascular, renal, respiratory, hematologic, gastrointestinal, dermatologic, or neurological systems) and no other probable diagnoses; or who have recently been infected with SARS-CoV-2 (COVID-19) as confirmed by RT-PCR, serology, or antigen testing; or who have been exposed to COVID-19 without suspecting any other possible diagnosis. Aim: to analyze COVID-19 associated MIS-C by recognizing its signs, symptoms (particularly neurological manifestations), investigation, treatment, and prognosis. Methods: This study focuses on children with neurological symptoms to better understand MIS- C's etiology, symptoms, diagnosis, and prognosis in  Beni-Suef university hospital Pediatrics  ICU. 39 kids was included  Results: This study evaluated the signs, symptoms, investigation, therapy, and prognosis of MIS-C in COVID-19-infected children. 14 women (37.5%) and 25 males (62.5%) were included. Their ages ranged from 1.5 to 180 months, with a mean of 52.5 months. The average duration of stay was 9.1 days, ranging from 1 to 22 days. This study of ( 39 ) individuals showed that Misc patients commonly have problems in other organ systems. The neurological manifestation amonge studied patients showed that  (30) case suffered from convulsion of different types, ( 6 ) cases suffered from headache ,  (20)  case ssuffered from encephalopathy, ( 2) cases had acute flaccid paralysis and only one case suffred from acute cerebellar ataxia . 77% of patients have respiratory symptoms (cough, dysnea, cyanosis), 42% have gastrointestinal symptoms (vomiting, diarrhoea, abdominal pain), 30% have cardiac symptoms (shock and hypotension), and 17.5% have renal symptoms (hypertension, oedema, oligiurea). Conclusions  The neurological manifestation amonge MIS-C patients are very common including convulsions of different types , headache , encephalopathy, ataxia , acute flaccid paralysis and we notice that , patients with more  sever neurological manifestations and had more than 2 organ system affections had poor prognosis  (morbidity and mortality) while patients received early treatment IVIG and methyel prednsilone had better prognosis.
Keywords
COVID-19; neurologic; MIS-C; Pediatrics
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