Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene) | ||
| Sinai International Scientific Journal | ||
| Volume 1, Issue 2, October 2024, Pages 18-34 PDF (1.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/sisj.2024.389245 | ||
| Authors | ||
| Esraa M. El-nshar* 1; El-Refaie Kenawy2; Mohamed M. Azaam3; Sahar H. El-Khalafy2 | ||
| 1Chemistry Department, Faculty of Dentistry, Sinai University, Kantara, Egypt. | ||
| 2Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt | ||
| 3Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt. | ||
| Abstract | ||
| The development of novel antimicrobial polymers is one of the most promising methods for preventing the growth of germs and limiting the spread of infections in a range of applications. Modified polymers have attracted an interest in biological activities. A series of modified poly (p-hydroxystyrene) was screened for in vitro antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli) and fungi (Candida albicans). Through the utilization of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, the antioxidant activities were examined. To evaluate each compound's affinity and binding pattern towardsthe E. coli protein active site, molecular docking was used. The modification was performed by chloroacetylation, then amination with 1,2-ethylenediamine and finally, the Schiff base compound was produced by condensation of 3-hydroxy-4- methoxybenzaldehyde with the polymer terminated with an amino group. The resulting compounds' structure was confirmed using FT-IR, elemental analysis, TGA and XRD. All synthesized compounds were identified and characterized. The prepared S-BPHS compound showed potential antioxidant and antimicrobial activities. | ||
| Keywords | ||
| Poly(hydroxystyrene); Schiff base; docking; antibacterial; antioxidant | ||
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