Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene)
El-nshar, E., Kenawy, E., Azaam, M., El-Khalafy, S. (2024). Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene). EKB Journal Management System, 1(2), 18-34. doi: 10.21608/sisj.2024.389245
Esraa M. El-nshar; El-Refaie Kenawy; Mohamed M. Azaam; Sahar H. El-Khalafy. "Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene)". EKB Journal Management System, 1, 2, 2024, 18-34. doi: 10.21608/sisj.2024.389245
El-nshar, E., Kenawy, E., Azaam, M., El-Khalafy, S. (2024). 'Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene)', EKB Journal Management System, 1(2), pp. 18-34. doi: 10.21608/sisj.2024.389245
El-nshar, E., Kenawy, E., Azaam, M., El-Khalafy, S. Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene). EKB Journal Management System, 2024; 1(2): 18-34. doi: 10.21608/sisj.2024.389245

Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene)

Sinai International Scientific Journal
Volume 1, Issue 2, October 2024, Page 18-34  XML PDF (1.01 MB)
Document Type: Original Article
DOI: 10.21608/sisj.2024.389245
View on SCiNiTO View on SCiNiTO
Authors
Esraa M. El-nshar email orcid 1; El-Refaie Kenawy2; Mohamed M. Azaam3; Sahar H. El-Khalafy2
1Chemistry Department, Faculty of Dentistry, Sinai University, Kantara, Egypt.
2Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt
3Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
Abstract
The development of novel antimicrobial polymers is one of the most promising
methods for preventing the growth of germs and limiting the spread of infections in 
a range of applications. Modified polymers have attracted an interest in biological
activities. A series of modified poly (p-hydroxystyrene) was screened for in vitro 
antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus),
Gram-negative bacteria (Escherichia coli) and fungi (Candida albicans). Through 
the utilization of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, the antioxidant
activities were examined. To evaluate each compound's affinity and binding pattern 
towardsthe E. coli protein active site, molecular docking was used. The modification 
was performed by chloroacetylation, then amination with 1,2-ethylenediamine and
finally, the Schiff base compound was produced by condensation of 3-hydroxy-4-
methoxybenzaldehyde with the polymer terminated with an amino group. The
resulting compounds' structure was confirmed using FT-IR, elemental analysis,
TGA and XRD. All synthesized compounds were identified and characterized. The 
prepared S-BPHS compound showed potential antioxidant and antimicrobial activities.
Keywords
Poly(hydroxystyrene); Schiff base; docking; antibacterial; antioxidant
Statistics
Article View: 140
PDF Download: 155