HISTOPATHOLOGICAL EFFECT OF PARAQUAT DICHLORIDE ON THE LIVER OF PREGNANT WISTAR RATS AT VARIOUS TRIMESTER | ||
| The Egyptian Journal of Forensic Sciences and Applied Toxicology | ||
| Volume 24, Issue 3, September 2024, Pages 121-127 PDF (1.17 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejfsat.2024.284964.1325 | ||
| Authors | ||
| santos ehebha* 1; Efe Endurance Ahama2; Emmanuel Igho Odokuma3 | ||
| 1=2348020760311 | ||
| 2Human Anatomy and Cell Biology | ||
| 3HUMAN ANATOMY AND CELL BIOLOGY, BASIC MEDICAL SCIENCES, COLLEGE OF HEALTH SCIENCES, DELTA STATE UNIVERSITY, ABRAKA. DELTA STATE, NIGERIA consultant Pathology Delta State University teaching hospital Oghara. Delta State | ||
| Abstract | ||
| Background: Paraquat dichloride, a widely used herbicide, poses health and environmental risks due to its wide range of use in the modern-day Argo life, endangering aquatic life, farm animals, rodents and human health particularly, liver-related ailments, the aim of the study is to evaluate the effect of paraquat on the liver of pregnant Wistar rats at various trimesters. Material and Method: The study involved 24 pregnant Wistar rats divided into four groups: A (control), B, C and D (treated with 1mg/kg, 5mg/kg, 10mg/kg concentration of paraquat dichloride) each group comprised six rats. Throughout each trimester, two rats from each group were euthanize on day 7, 14, and 21 respectively. The concentrations (1mg/kg, 5mg/kg, 10mg/kg) were chosen below the lethal dose of 50mg/kg to induce graded dose histological changes in the liver. Result: The liver tissue initially appeared normal at day 7 across all group with varying doses. However, by day 14 and 21, significant histological changes were observed, such as central vein congestion, hemorrhages, degenerative changes, and bile duct hyperplasia. Conclusion: These finding highlight the changes that occurs with varying doses of paraquat exposure in the liver as pregnancy progresses in Wistar rats. | ||
| Keywords | ||
| Paraquat; liver; Histology; Wistar rats; Trimester; Doses | ||
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