Nano-Vaccines: Pioneering the Future of Immunization

Ebrahim, Yasmin Y.; Elsayed, Aya G.; Ebrahim, Rewan A.; Kaoud, Eptehal A.; Darhous, Shams M.; Zaki, Nourhan H.; Hegazi, Aya A.; Elnosary, Aya N.; Othman, Abdelrahman I.; Youssef, Youstina L.; Megahed, Mohamed A.

doi:10.21608/erurj.2024.292340.1153

	Nano-Vaccines: Pioneering the Future of Immunization
ERU Research Journal
Volume 4, Issue 2, April 2025, Page 2366-2399 PDF (741.2 K)
Document Type: Review article
DOI: 10.21608/erurj.2024.292340.1153
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Authors
Yasmin Y. Ebrahim¹; Aya G. Elsayed¹; Rewan A. Ebrahim¹; Eptehal A. Kaoud¹; Shams M. Darhous¹; Nourhan H. Zaki¹; Aya A. Hegazi¹; Aya N. Elnosary¹; Abdelrahman I. Othman ²; Youstina L. Youssef ²; Mohamed A. Megahed ²
¹PharmD student, Faculty of Pharmacy, Egyptian Russian University, Badr city, Cairo, Egypt.
²Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt
Abstract
Nanotechnology has revolutionized vaccine development by offering precise control over antigen delivery, adjuvant properties, and immune response modulation. This review examines recent nano-vine design advancements, focusing on their potential applications in infectious diseases and cancer disorders. This review systematically examines the various types of nano vaccines, elucidating their unique properties and applications in vaccine development. Furthermore, the review explores the versatility of nano-vaccine delivery routes and discusses their respective advantages and challenges in eliciting potent immune responses. Despite their promise, nano-vaccines encounter multifaceted difficulties, ranging from biocompatibility and immunogenicity to manufacturing scalability and regulatory hurdles. Nano-vaccines have opened an entrance to boundless hopes in efficiently preventing pathogenic, cancerous, and non-infectious diseases in immune-tolerant individuals. Despite the formidable challenges in toxicity, scaling up, and regulations in nano-vacinnes, more research focused on collaboration with commercial industries can lead to the rapid commercialization of nano-vaccines. Future directions in nano-vaccine research are proposed to optimize their clinical translation and maximize their therapeutic impact.
Keywords
Nanotechnology; Vaccines; Future psospects


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