Effect of Ketogenic Diet on Colonic Changes of Stress Induced Irritable Bowel Syndrome of Adult Male Albino Rat Model (Histological and Morphometric study) | ||||
| Ain Shams Medical Journal | ||||
| Volume 75, Issue 3, September 2024, Page 619-636 PDF (8.58 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2024.311338.1295 | ||||
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| Authors | ||||
Hala Taha Shalan1; Rana Ashraf Fathy2; Maha khaled El-Ashry3; Enas Anwar Bekheet   4
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| 1Anatomy department, Faculty of Medicine, Ain Shams university | ||||
| 2Anatomy department, Faculty of Medicine, Ain Shams University | ||||
| 3Anatomy Department, Faculty of Medicine, Ain Shams University | ||||
| 4Anatomy Department, Faculty of Medicine , Ain Shams University | ||||
| Abstract | ||||
| Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder. Psychological stress is identified as a trigger for IBS. Research on the effectiveness of the ketogenic diet for treating IBS remains limited. Aim of the work: This work aimed to evaluate the effectiveness of ketogenic diet in mitigating colonic changes associated with experimentally induced irritable bowel syndrome in adult male albino rats. Material and methods: Thirty adult male albino rats were used, divided equally into three groups: - Control Group (Group I): Rats were fed a standard diet for ten days and then continued the same diet for an additional ten weeks without being exposed to water avoidance stress (WAS). - IBS Group (Group II): Rats were fed a standard diet and subjected to WAS for ten days and then continued a standard diet for ten weeks. - IBS-KD Group (Group III): Rats were fed a standard diet initially and exposed to WAS for ten days and then switched to ketogenic diet (KD) for ten weeks. Results: Rats of the IBS group, which were fed a standard diet, showed several histological alterations of the descending colon, such as an irregular surface mucosal epithelium with detached cells in the lumen of the colon, degenerated colonocytes, a few goblet cells and large mast cells. In contrast, rats of the IBS-KD Group that were fed a ketogenic diet showed an almost regular histological structure of the descending colon. Conclusion: Ketogenic diet could be regarded as a potentially beneficial approach for irritable bowel syndrome. | ||||
| Keywords | ||||
| Colon; Irritable bowel syndrome; Ketogenic diet | ||||
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