In- vitro evaluation of blood bags based on poly(vinyl chloride)/ selenium nanocomposites and exposed to electron beam irradiation | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 6, June 2025, Page 129-145 PDF (1.51 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.303268.9984 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
H. M. Eyssa   1; Marwa. Abd El Hameed. Mohamed2; Heba M. El Refay 3; M. H. Sanad4
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| 1Radiation Chemistry Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt. | ||||
| 2Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt. | ||||
| 3Chemistry Department, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Nasr City, Cairo, Egypt. | ||||
| 4Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, Egypt. | ||||
| Abstract | ||||
| In this study, the potential benefits of incorporating green synthesized selenium nanoparticles (Se NPs) into blood bags based on poly(vinyl chloride) (PVC) and then exposed to electron beam (EB) is exposed. In addition to the in-vitro assessment of its impact on the preservation of blood components. In this context, Se NPs were synthesized using a green garlic extract, as reducing and stabilizing agent. The EB irradiated PVC blood bags incorporated with Se NPs were characterized with FT-IR spectroscopic, mechanical testing, thermogravimetric analysis (TGA) and blood compatibility. The results showed that Se NPs and electron beam irradiation improved both thermal stability and mechanical properties. The assessment involved the participation of three healthy volunteers for the in- vitro study. For each volunteer, a set of five blood bags were used, including a control bag (market bag), PVC bag, PVC bag with dioctyl phthalate (DOP), PVC bag with 0.5%, 1% and 2% Se NPs, as a comparative study. The hemoglobin content (HB), red blood cells (RBCs), and hematocrit (HCT %) were measured at regular intervals of 1, 2, 3, 4, 5, and 6 weeks. The results indicated that the PVC blood bag incorporated with 0.5 % Se NPs demonstrated a good preservation of blood components. The HB concentration, RBCs, and HCT % remained stable over the six-week period, indicating minimal degradation or loss of blood quality. These findings implied that using green synthesized Se NPs in PVC blood bags had a positive impact on the long-term preservation of blood components. Further research is warranted to explore the mechanisms underlying the enhanced preservation properties of Se NPs-incorporated PVC blood bags and to ensure their safety and efficacy in clinical settings. | ||||
| Keywords | ||||
| Medical grade PVC; Green synthesized selenium nanoparticles; Hemolytic test; Electron beam radiation; blood bag | ||||
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