Role of Macrophage Migration Inhibitory Factor in Prediction of Cardiac Affection in Multisystem Inflammatory Syndrome in Children | ||||
| The Medical Journal of Cairo University | ||||
| Volume 92, Issue 09, September 2024, Page 667-677 PDF (699.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2024.389765 | ||||
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| Author | ||||
| LAMYAA SALEM, M.D.** and EMAN M. EL SAYED, M.D.* ABDELRAHMAN M.A. FARAG, M.Sc.*; ALYAA A. KOTBY, M.D.*; NEHAD A. BAKRY, M.D.*; | ||||
| The Departments of Pediatrics* and Clinical Pathology**, Faculty of Medicine, Ain Shams University | ||||
| Abstract | ||||
| Abstract Background: Multisystem inflammatory syndrome in chil-dren (MIS-C) is a dysregulated immune response to viral infec-tion by COVID-19 accompanied by systemic manifestations. Macrophage migration inhibitory factor (MIF) exerts inhibitory effects on macrophage migration and is raised in adult cardiac critical illness Aim of Study: To identify the role of MIF as a marker of cardiac affection in MIS-C patients. Patients and Methods: This case-controlled study was con-ducted on 24 MIS-C children and 24 apparently healthy con-trols. Clinical and laboratory data were compared between both groups. Echocardiography was done for all participants. Results: Myocardial injury markers as troponins, CK-MB and liver injury markers were significantly (p>0.05) elevated among MIS-C patients than controls. MIF expression was also significantly higher (p>0.05) among MIS-C patients. Impaired LV function and valve regurgitation were the main echocardio-graphic findings among MIS-C patients. MIF correlated sig-nificantly with age, lymphocytic count, ferritin, LDH, D-dimer, CK-MB, EF%, LVESD, LVEDD, Z-score RCA and Z-score LCA. Conclusion: Myocardial injury is common in MIS-C pa-tients. Impaired LV function is the most prominent echocardio-graphic finding. MIF could be considered as a biomarker for MIS-C and correlated significantly with myocardial affection among those patients. | ||||
| Keywords | ||||
| Multisystem Inflammatory Syndrome; COVID-19 in Children | ||||
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