Optimizing a Convenient Protocol in Induction Treatment Of Locally Advanced Head And Neck Cancers: Taxotere- Cisplatin- 5 Fluorouracil versus Cisplatin-5 Fluorouracil | ||||
| SECI Oncology Journal | ||||
| Article 4, Volume 12, Issue 4, October 2024, Page 353-358 | ||||
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| Abstract | ||||
| Background: Induction docetaxel cisplatin and 5-fluorourcil (TPF) followed by concomitant chemoradiotherapy (CT/RT) in locally advanced squamous cell carcinoma of the head and neck (LASCCHN) is the most efficacious strategy but on the other hand it lowers the compliance of the patients due to its high toxicity. We preferred to use the cisplatin 5-fluorouracil (PF) as induction due to better compliance and lower toxicity. Materials and methods: A total of 52 patients received either TPF of PF as induction before chemoradiation were studied retrospectively. Treatment compliance, febrile neutropenia and response rates (RR) were analyzed as well as progression free survival (PFS) Results: Treatment delays during chemotherapy were much lower in the PF arm compared to TPF 1/25 (4%) versus7/27 (25.9%) respectively with significant P value (P=0.051). Neutropenia G3-4 with PF was significantly lower than the TPF regimen 8% (2/25) versus 40.7% (11/27) (P=0.06). RR (CR+PR) after concomitant CT/RT was almost the same in both arms 88% in the PF versus 85.2% in the TPF with non-significant P value. Comparison of progression-free survival (PFS) between PF group and TPF group showed no significant difference (p=0.305).at 18 months follow up, the PFS at PF arm was 75.4 % vs 92.1% in the TPF arm. Conclusion: Induction PF protocol suits better our population as it yielded better compliance, lesser toxicity with maintaining the same efficacy. | ||||
| Keywords | ||||
| locally advanced squamous cell carcinoma head and neck; TPF; PF; chemoradiotherapy | ||||
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