Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans
Wafaey, A., El Hawary, S., ismail, S., Mohamed, S., Abdelhameed, M., kirollos, F. (2025). Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans. EKB Journal Management System, 68(6), 27-41. doi: 10.21608/ejchem.2024.323274.10497
Aya A. Wafaey; Seham El Hawary; shaymaa Abdalla ismail; Sherif Salah Mohamed; Mohamed Fayed Abdelhameed; farid kirollos. "Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans". EKB Journal Management System, 68, 6, 2025, 27-41. doi: 10.21608/ejchem.2024.323274.10497
Wafaey, A., El Hawary, S., ismail, S., Mohamed, S., Abdelhameed, M., kirollos, F. (2025). 'Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans', EKB Journal Management System, 68(6), pp. 27-41. doi: 10.21608/ejchem.2024.323274.10497
Wafaey, A., El Hawary, S., ismail, S., Mohamed, S., Abdelhameed, M., kirollos, F. Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans. EKB Journal Management System, 2025; 68(6): 27-41. doi: 10.21608/ejchem.2024.323274.10497

Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans

Egyptian Journal of Chemistry
Volume 68, Issue 6, June 2025, Pages 27-41    PDF (1.43 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.323274.10497
Authors
Aya A. Wafaey* 1; Seham El Hawary2; shaymaa Abdalla ismail3; Sherif Salah Mohamed4; Mohamed Fayed Abdelhameed5; farid kirollos6
1Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University
3Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El-Bohouth St., Dokki, Cairo 12622, Egypt.
4National Research Centre, Dokki, Cairo, Egypt
5Pharmacology department, medical division, national research centre
6department of pharmacognosy, faculty of pharmacy, Cairo university
Abstract
The study analyzed the chemical composition and antimicrobial activity of essential oils and lipids from Gliricidia sepium (Jacq.) Kunth. ex. Walp. leaves and flowers. Gas chromatography-mass spectrometry analysis (GC-MS) revealed high levels of unsaturated fatty acids, with arachidonic acid being the most abundant in both leaves (39.56%) and flowers (83.66%). The leaves had high hydrocarbons, including betulin (29.23%), while the flowers contained a mix of hydrocarbons and sterols/triterpenoids, with betulin (44.39%) as the main compound. The GC-MS analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. essential oils found eucalyptol (24.09%) and d-limonene (18.05%) as the main components in the flowers, while coumarin (33.52%) and estragole (15.48%) were the chief components in the leaves. Essential oils from leaves and flowers were mostly inactive against several bacteria and fungi, but the leaves' essential oil showed antifungal activity against fluconazole-resistant Candida albicans and weak activity against Salmonella typhi. The antifungal effect of the leaves' essential oil is likely due to coumarin, estragole, and betulin
Keywords
Lipid profile; Essential oils; Gliricidia sepium (Jacq.) Kunth. ex. Walp; Antifungal activity; Fluconazole-resistant Candida albicans
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