The Effect of Intravitreal Injection of Anti-VEGF on Perfusion Indices in Eyes with Diabetic Macular Edema Measured by Optical Coherence Tomography Angiography | ||||
| The Medical Journal of Cairo University | ||||
| Volume 92, Issue 09, September 2024, Page 717-727 PDF (176.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2024.389841 | ||||
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| Author | ||||
| ABD EL RAHMAN G. SALMAN, M.D.; MOUAMEN M. MOSTAFA, M.D.; HATEM F. ABD ELFATAH, M.D. MOSTAFA G. MANSOUR, M.Sc. | ||||
| The Department of Ophthalmology, Faculty of Medicine, Ain Shams University | ||||
| Abstract | ||||
| Abstract Background: Anti-VEGF agents interfere with receptor binding, thus inhibiting VEGF’s signal, which results in inhi-bition of abnormal blood vessel formation and decreased vas-cular permeability. Anti-VEGFs have significant roles in the treatment of many retinal diseases as age related macular de-generation, myopic choroidal neovascularization, proliferative diabetic retinopathy, diabetic macular edema and retinal vein occlusion. Aim of Study: To evaluate changes in macular vessel den-sity following first dose of intravitreal anti-VEGF injection of ranibizumab (Lucentis®) in patients with diabetic macular ede-ma (DME). Patients and Methods: This prospective study included 44 eyes of 44 DME patients indicated for IVI of Ranibizumab, with mean age 50.98±6.27 years, ranging from 41.0 years to 60.0 years. The majority of them were males (68.2%). Results: Vessel density (central subfield) at baseline (20.29 ±1.89) didn’t show statistically significant difference than that at one month (20.09±2.4) but showed a highly significant differ-ence at two months (19.73±2.49) after IVI. Vessel density (av-erage of the four parafoveal sub fields) at baseline (44.98±2.6) didn’t show statistically significant difference than that at one month (44.8±2.21) but showed a highly significant difference at two months (44.14±2.2) after IVI. Conclusion: A single IV injection of Ranibizumab in eyes with DME showed non significant vascular density changes after one month of injection in both central and paraoveal sub-fileds but a statistically significant decrease in vascular density 2 months after injection. | ||||
| Keywords | ||||
| Diabetic macular edema; Intra retinal microvas-cular abnormalities | ||||
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