Dose – Related Amiodarone induced Thyrotoxicity in Adult Albino Rat and its Possible Reduction by Vitamin E: Histological and Immunohistochemical Study | ||||
| Journal of Medical Histology | ||||
| Article 6, Volume 7, Issue 2, December 2023, Page 255-263 PDF (688.63 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmh.2022.149161.1101 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Mohamed Abdel Moaty 
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| Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt | ||||
| Abstract | ||||
| Introduction: Amiodarone (AMN) is one of the most common anti-arrhythmic drugs having many harmful effects on many organs such as the thyroid gland. The aim of the present study is to delineate the possible protective action of vitamin E to ameliorate the AMN induced thyrotoxicity. Materials and Methods: 20 rats were utilized and divided into group I were given no medications, group II were given half the therapeutic dose of amiodarone, group III were given the therapeutic dose of amiodarone orally and group IV were given the therapeutic dose of amiodarone and vitamin E. after 3 weeks, all rats were sacrificed and the thyroids were examined histologically and histochrmically for Bax. The sera were analyzed for the inflammatory markers including CRP and P53. Results: The thyroids showed amiodarone related histological and histochemical alterations with hormonal and inflammatory disturbances. It was concluded that vitamin E could reduce the amiodarone induced thyrotoxicity. Conclusions: QU-CSNPs has prophylactic effects in an anosmia model than QU via its anti-inflammatory and antioxidant effects. This could pave the way for additional studies to investigate further mechanisms underlying the potential beneficial effects of QU-CSNPs and bring up a new line for anosmia therapy. | ||||
| Keywords | ||||
| Amiodarone; Bax; thyroid and vitamin E | ||||
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