Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis
Asal, D., Wahba, A., Hazem, R., Mesbah, N., Abo-El-Matty, D., Ramadan, A. (2024). Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis. EKB Journal Management System, 8(1), 179-190. doi: 10.21608/rpbs.2024.327923.1331
Dalia mohamed Asal; Alaa S. Wahba; Reem Hazem; Noha Mesbah; Dina Abo-El-Matty; Asmaa Ramadan. "Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis". EKB Journal Management System, 8, 1, 2024, 179-190. doi: 10.21608/rpbs.2024.327923.1331
Asal, D., Wahba, A., Hazem, R., Mesbah, N., Abo-El-Matty, D., Ramadan, A. (2024). 'Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis', EKB Journal Management System, 8(1), pp. 179-190. doi: 10.21608/rpbs.2024.327923.1331
Asal, D., Wahba, A., Hazem, R., Mesbah, N., Abo-El-Matty, D., Ramadan, A. Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis. EKB Journal Management System, 2024; 8(1): 179-190. doi: 10.21608/rpbs.2024.327923.1331

Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis

Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 1, 2024, Page 179-190  XML PDF (929.75 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2024.327923.1331
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Authors
Dalia mohamed Asal email 1; Alaa S. Wahbaorcid 1; Reem Hazemorcid 2; Noha Mesbahorcid 1; Dina Abo-El-Mattyorcid 1; Asmaa Ramadan3
1Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
2Pharmacology & toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
3Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Abstract
Diabetic nephropathy (DN) stands out as one of the most significant complications of diabetes mellitus, and it is a primary contributor to end-stage kidney disease globally. The progression of DN is complex, involving intricate interplays, including oxidative stress, inflammation, fibrosis, and cellular apoptosis. Recently, scientific investigations have emphasized the significant role of the sigma-1 receptor (S1R) and nuclear factor erythroid 2-related factor 2 (Nrf2) in mitigating these detrimental effects. Scientific evidence indicated that the activation of S1R could effectively diminish cellular oxidative stress, inflammation, and cell death, alleviating renal damage in diabetic nephropathy. Nrf2, a key regulator of antioxidant responses, protects renal cells from oxidative injury and modulates inflammatory responses. Targeting S1R and Nrf2 may provide novel therapeutic approaches for managing diabetic nephropathy. This review offers a detailed overview of the pathophysiological mechanisms underlying DN, focusing on the S1R/Nrf2 axis and its potential as a promising therapeutic target for diabetic nephropathy.
Keywords
Diabetic nephropathy; oxidative stress; inflammation; apoptosis; S1R/Nrf2
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