THE ASSOCIATION BETWEEN THE LEVEL OF VITAMIN K2 IN BLOOD AND THE SEVERITY OF SYMPTOMS IN IDIOPATHIC PARKINSONIAN PATIENTS | ||
| ALEXMED ePosters | ||
| Article 1, Volume 6, Issue 4, September 2024, Pages 49-50 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2024.333650.1991 | ||
| Authors | ||
| Horeya SaadAllah1; Jaidaa Farouk Mekky2; Yasmin Amr Issa3; Yara Ehab Moustafa El Azab* 4 | ||
| 1Department of Neuropsychiatry ,Faculty of Medicine, University of Alexandria. | ||
| 2Department of Neuropsychiatry, Faculty of Medicine, Alexandria University. | ||
| 3Department of Medical Biochemistry, Alexandria Faculty of Medicine | ||
| 4Department of Neuropsychiatry, Faculty of Medicine, Alexandria University | ||
| Abstract | ||
| INTRODUCTION: Parkinson's disease (PD) is a progressive neurodegenerative disorder that might result in death, and affects ~1–3% of the global population aged from 40 years to above 60 years. There are two forms of PD: familial; genetically inherited in either an autosomal dominant or recessive manner, and sporadic (idiopathic); believed to develop from gene-environment interactions. Idiopathic Parkinson’s disease (IPD) is the most common neurodegenerative disorder after Alzheimer’s disease. The major motor symptoms of IPD are resting tremor, bradykinesia, rigidity, and postural reflex disturbance. Apart from these dopaminergic motor symptoms, non-motor symptoms also develop secondary to serotonergic, noradrenergic, cholinergic, and autonomic nervous system involvement. Non-motor symptoms include major neuropsychiatric symptoms such as cognitive dysfunction, autonomous disorders, sleep disorders, and sensory symptoms. Underlying many of the motor symptoms of PD is the selective loss of dopaminergic neurons of the substantia nigra pars compacta and their principal axon projections to the striatum. AIM OF THE WORK: The aim of this study was to investigate the association between circulating level of vitamin K2 and the severity of symptoms in idiopathic Parkinson’s Disease patients. | ||
| Keywords | ||
| LEVEL; BLOOD; PARKINSONIAN | ||
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