Anti-hyperlipidemic effect of Purslane on high fat-diet-induced hyperlipidemic rats | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 7, July 2025, Page 365-377 PDF (1.85 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.322116.10457 | ||||
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| Authors | ||||
Sohier E El-Sherbeny1; Samah A El-Newary   2; Mohamed S. Aly 3; Wael M. Elsayed4; Abdelghany A. Youssef1
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| 1Department of Medicinal and Aromatic Plants Research | ||||
| 2Medicinal and Aromatic Plants Research Department, National Research Centre | ||||
| 3Animal Reproduction and Artificial Insemination Department, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt | ||||
| 4Chemistry of Medicinal Plants Department | ||||
| Abstract | ||||
| Purslane (Portulaca oleracea ver. oleracea, family Portulacaceae) is known as a “vegetable for long life". Many medicinal uses are attributed to Purslane as an antispasmodic, diuretic, anti-scorbutic, wound-healing, analgesic, anti-inflammatory, bronchodilator, antipyretic, anti-asthma, and antitussive. This study was carried out to evaluate the hypolipidemic and antioxidant activity of purslane leaf powder and its infusion in high-fat diet-induced hyperlipidemic rats. Purslane leaves powder (PLP7.50% and PLP15.00%) and infusion (1g/kg/day orally) were tested on hyperlipidemic rats for 30 and 60 days. Administration of purslane forms reduced DBWG, FI, TL, TG, TC, LDL-C, and VLDL-C significantly compared with HFD-control. As well as a decreased risk ratio nearly to a typical case. Purslane returned the lipid profile of rats towards normalization. Both liver and kidney functions of HFD-control were distributed significantly. Administration purslane improved them significantly compared with HFD-control. The liver of HFD-control showed fatty changes as micro and macro-steatosis. Purslane leaf powder decreased fat accumulation in the liver, and the liver appeared to have a standard structure concerning HFD-control liver. Purslane leaves powder and its infusion contained polyphenolics, flavonoids, tannins, mucilage, and alkaloids. | ||||
| Keywords | ||||
| Purslane leaves and infusion; hypolipidemic effect; risk ratio; polyphenols and mucilage; Histological examination | ||||
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