Vanin– 1 Protein Level Among Primary Immune Thrombocytopenic Purpura Cases | ||||
| Al-Azhar University Journal of Medical and Virus Researches and Studies | ||||
| Volume 6, Issue 3, September 2024, Page 1-9 PDF (396.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aujv.2024.391234 | ||||
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| Abstract | ||||
| The development of chronic ITP may be linked to vanin-1 overexpression. When blood mononuclear cells were subjected to oxidative stress inducers, VNN1 was markedly upregulated and PPARg was markedly downregulated. These results show that VNN1 serves as a peripheral blood oxidative stress sensor. The current study aimed to measure Vanin -1 protein level by ELISA as a predictive factor in patients with primary immune thrombocytopenic purpura. A Comparative, case-control study, included 30 primary ITP cases along with 20 healthy subjects as a control group. A comprehensive clinical examination, a complete history taking, and laboratory investigation (Vanin-1 protein level by ELISA) were performed on all patients. The level of Vanin-1 level was significantly higher among ITP cases compared to the controls. There were no statistically significant correlations between Vanin-1 levels and laboratory findings among ITP patients except for HCT (%) which shows a significant negative moderate correlation with Vanin-1. Analysis of the ROC curve shows that Vanin-1 can discriminate ITP patients from healthy controls, with a highly significant difference. Using coordinate points of the above ROC curve, the most relevant level of Vanin-1 is 0.7 to differentiate ITP patients from healthy controls, with a sensitivity of 100%, and a specificity of 95%. Vanin -1 can be used as a predictive factor to differentiate ITP cases from healthy non-diseased subjects. | ||||
| Keywords | ||||
| Cystic lesions; MDCT; Chest | ||||
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