Outcomes of Curcumin addition to Statin Therapy in Dyslipidemia Patients at High Risk: A Placebo-Controlled Trial | ||
| The Egyptian Family Medicine Journal | ||
| Volume 8, Issue 2, November 2024, Pages 53-68 PDF (717.04 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/efmj.2024.270982.1130 | ||
| Authors | ||
| Doaa ElSayed Karama1; Safwat Abd El-Maksoud Ahmed2; Mosleh Abdelrhman Ismail3; Samy Abdelrazek Abdelazim1; Ismail Dahshan* 4 | ||
| 1Family medicine department, faculty of medicine, Suez Canal University, Ismailia, Egypt | ||
| 2Pharmacognosy Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||
| 3Family Medicine Department, Faculty of Medicine,Suez Canal University, Ismailia, Egypt | ||
| 4Family Medicine Department, Faculty of Medicine, Suez Canal University, | ||
| Abstract | ||
| Abstract Background: Dyslipidemia is one of the world’s most prevalent & fatal diseases. Curcumin is an herbal remedy that may help improve dyslipidemia patterns. Some studies investigated the role of curcumin as a potential adjunct therapy in the management of dyslipidemia; the outcomes of such studies were conflicting. Objectives: This study was conducted to assess the outcomes of curcumin supplementation with statin therapy on dyslipidemia patients attending a Family Medicine Center in Ismailia, Egypt. Methodology: This study was conducted as a double-blind, randomized placebo-controlled trial. A total of 118 patients with dyslipidemia profiles at high risk were randomly assigned to two groups; an intervention group that received 1 g curcumin capsule once daily and a control group that received a placebo capsule of 1 g starch powder once daily, in addition to the statin drug (atorvastatin 40 mg) that was prescribed to all participants. The outcomes were assessed at baseline, 6 weeks, and 12 weeks. Results: When compared to the placebo group, the curcumin group showed a significant reduction in both LDL-C and total cholesterol. In the mixed ANOVA analysis results, the time component of the study had a larger effect size for all participants than the interaction between time and group of intervention. Conclusion: According to the study's findings, curcumin reduced LDL-C and total cholesterol in a statistically significant manner when added to high-intensity statin medication. It is necessary to conduct more research to determine curcumin's exact effect in patients with lipid profiles at low and moderate risk | ||
| Keywords | ||
| Herbal; hyperlipidemia; primary care; addition | ||
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