A STUDY OF TRANSFORMING GROWTH FACTOR – BETA IN CHILDREN WITH ACUTE LEUKEMIA IN ALEXANDRIA UNIVERSITY CHILDREN’S HOSPITAL | ||
| ALEXMED ePosters | ||
| Article 1, Volume 6, Issue 4, September 2024, Pages 58-59 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2024.332171.1988 | ||
| Authors | ||
| Hala Mohamed Assem1; Mohamed Ebrahim Elshinawy1; Wessam Mohamed ElGendy2; Nehad Mohamed Hassanein1; Muzamil Abdalla Mohamed Haji* 1 | ||
| 1Department of Pediatrics, Faculty of Medicine, Alexandria University | ||
| 2Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University | ||
| Abstract | ||
| Leukemia arises from the clonal proliferation of abnormal hematopoietic cells, leading to disruption of normal marrow function and marrow failure. Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis. The functions of TGFβ are not limited to the regulation of proliferation, differentiation, apoptosis, epithelial–mesenchymal transition, and metastasis of cancer cells. Dysregulation of TGFβ family signaling can lead to a plethora of developmental disorders and diseases, including cancer, immune dysfunction, and fibrosis. TGFβ as a target for cancer therapy. Thus, by combining chemotherapy, targeted therapy, radiotherapy, and immunotherapy with TGFβ-targeting drugs, treatments can be made more efficient by improving antitumor efficacy and reducing therapy resistance. AIM OF THE WORK: The aim of this study was to: Evaluate Transforming growth factor- beta (TGFβ) in children with acute leukemia before induction of remission and during maintenance chemotherapy. To find the relationship (if any) of TGFβ to type and risk stratification of leukemia | ||
| Keywords | ||
| TGFβ; ACUTE LEUKEMIA; chemotherapy | ||
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