Increased CD3 immunostaining associated with high grade and tumor size in colorectal carcinoma | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 23, Volume 34, Issue 1, January 2025, Page 205-212 PDF (578.83 K) | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2024.331363.1364 | ||||
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| Authors | ||||
Oula Alalwany1; Dhafer A. Alghezi   1; Rasha Q. Aljawher2; Ali Harb3
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| 1Department of Medical Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, 64001,Iraq | ||||
| 2Department of Histopathology and Forensic Medicine, College of Medicine, University of Thi-Qar, Thi- Qar, 64001,Iraq | ||||
| 3Department of Community Health Technologies, College of Health and Medical Technologies, National University of Science and Technology, Thi-Qar, Iraq | ||||
| Abstract | ||||
| Background: Colorectal cancer lacks reliable prognostic biomarkers, complicating the differentiation between aggressive and indolent tumors. While CD3+ T lymphocyte infiltration generally correlates with improved prognosis and response to immunotherapy, its specific role in tumor aggressiveness is not fully understood. Objective: This study aims to assess CD3+ T cell infiltration in benign and malignant colorectal tissues and explore its potential association with clinical outcomes. Methodology: Immunohistochemistry was used to assess CD3+ T cell staining in the stromal tissue of benign (n=24) and malignant (n=80) colorectal samples. CD3+ T cell expression was then correlated with clinic pathological data such as grade and stage. Results: CD3+ T cell infiltration was significantly higher in colorectal carcinoma than benign tissues (p=0.007). A positive association was observed between CD3+ T cell immunostaining and high tumor grade (p=0.002), while a negative correlation emerged between CD3+ T cell immunostaining and tumor size (p=0.005). No significant relationship was identified between CD3+ immunostaining and lymph node involvement. Conclusion: CD3+ T cells might be involved in the aggressiveness of malignancy. Further research is needed to determine the significance of CD3+ T cells in colorectal carcinoma and its potential as a biomarker for cancer progression. | ||||
| Keywords | ||||
| Colorectal Carcinoma; CD3; Immunohistochemistry; Tumor grades; Tumor invasion | ||||
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