INVESTIGATION OF THE IMPACT OF DIFFERENT FORMULATION AND PROCESSING PARAMETERS ON THE PHYSICOCHEMICAL PROPERTIES OF CURCUMIN-LOADED NANOSTRUCTURED LIPID CARRIERS | ||||
| Sphinx Journal of Pharmaceutical and Medical Sciences | ||||
| Volume 7, Issue 1, April 2024, Page 9-20 PDF (672.74 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/sjpms.2024.321648.1027 | ||||
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| Authors | ||||
Gamal Salaheldien Elattar  1; Ahmed El-Sayed Aboutaleb2; Aly Abdel-Zaher Abdel-Rahman3; Hesham Mohamed Tawfeek3
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| 1Department of Pharmaceutics, Faculty of Pharmacy, Sphinx University,New Assiut, Egypt | ||||
| 2Department of Industrial pharmacy, Faculty of pharmacy, Assiut University, Assiut, Egypt | ||||
| 3Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Nanostructured lipid carriers (NLCs) are drug delivery systems with remarkable physicochemical stability, biocompatibility, biodegradability and can offer controlled drug release. This study aimed to develop and characterize nanostructured lipid carriers (NLCs) containing curcumin (CUR-NLCs) as a primary step in improving curcumin delivery. The effect of certain formulation and processing parameters on the developed CUR-NLCs properties were investigated. In this work, different concentrations and types of surfactants (Pluronic F-127, Pluronic F-68, and Tween 80) were used to stabilize NLC dispersions. Moreover, two different solid lipids (Compritol 888 ATO and Precirol ATO 5) and several liquid lipids (Labrafac lipophile WL 1349, refined olive oil, oleic acid and glyceryl caprylate/caprate) were used. The emulsification/ultrasonication technique was employed to prepare the CUR-NLCs, either using a magnetic stirrer/probe sonicator method or rotorstator homogenizer/ultrasonic water bath method. The physical and chemical properties of the formulations were evaluated, including particle size, polydispersity index, and zeta potential. The obtained results showed that increasing surfactant concentration from 0.5 to 2% w/v and reducing the total lipid percentage by weight from 5 to 2% w/v had significant impact on the nanoparticle properties. Finally, the formulation with the lowest mean particle size diameter (59.49 ± 0.71 nm) with a zeta potential of –14.13 ± 1.06 mV and PDI of 0.27 was selected and it showed relatively high entrapment efficiency (75.33 ± 5.06%) and prolonged drug release (≈ 60% within 72 hours). | ||||
| Keywords | ||||
| NLCs; Particle size; PDI; Zeta potential; Drug Delivery | ||||
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