HUMAN CARTILAGE GLYCOPROTEIN 39" YKL-40"AS AN INDICATOR FOR LYMPH NODE AFFECTION IN PATIENTS WITH ENDOMETRIAL CARCINOMA | ||
| ALEXMED ePosters | ||
| Article 1, Volume 6, Issue 4, September 2024, Pages 61-62 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2024.333937.1995 | ||
| Authors | ||
| Helmy Helmy Abd El-Sattar Rady1; Ahmed Abdelazem Essmat2; Hebatallah H.M. Hassan3; Eman Saad Nassar4; Mohamed Reda Mohamed Etman* 5 | ||
| 1Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria | ||
| 2Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University | ||
| 3Radiodiagnosis, Faculty of Medicine , Alexandria University , Alexandria , Egypt | ||
| 4Department of Clinical and Chemical Pathology, Faculty of Medicine, University of Alexandria. | ||
| 5Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria. | ||
| Abstract | ||
| The most common tumor in the female genital system globally is endometrial cancer, with a global rise in incidence as well as disease-related morbidity and mortality. EC has diverse histological subtypes and molecular characteristics. In the past, EC was divided into two types: Type I is characterized by unopposed estrogen stimulation and includes more common low-grade cells with a favorable prognosis, and Type II, which is not estrogen-driven, includes less prevalent high-grade cells with a poor prognosis. Type I ECs consists of grade I or grade II endometrioid adenocarcinomas, while Type II ECs consist of serous clear cell, undifferentiated, carcinosarcomas, and grade III endometrioid adenocarcinomas. Chitinase-3 like-protein-1, also known as breast regression protein 39 (BRP-39) or YKL-40 in humans, is a common CLP found in both prokaryotes and eukaryotes. The three N-terminal amino acid residues—tyrosine (Y), lysine (K), and leucine (L)—that are present in the secreted form and have a molecular weight of 40 kDa have earned it the designation YKL-40. Aim of the work: The aim of this study was to compare YKL-40 as a marker for lymph node affection in patients with endometrial carcinoma to the available imagining study (Ct staging and / or MRI pelvis) and in relation to the histopathological examination of resected lymph nodes done at gyne-oncology unit at El Shatby Maternity University Hospital from January 2023 till May 2024. | ||
| Keywords | ||
| YKL-40; LYMPH NODE; ENDOMETRIAL CARCINOMA | ||
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