Stability constants, characterization, and Theoretical Modelling Studies of the Complexes of L- Ascorbic Acid with Transition Metal Ions | ||||
| Journal of Basic and Environmental Sciences | ||||
| Volume 11, Issue 4, October 2024, Page 483-500 PDF (1.53 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbes.2024.326386.1011 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
fatma mohammed elfeky  1; EMAN ALY MOHAMED2; sahar ibrahim3; moustafa shahin3
| ||||
| 1chemistry department , faculty of science , benha university | ||||
| 2Lecturer of chemistry Basic science department International academy for engineering and media science (IAEMS) | ||||
| 3department of chemistry , faculty of science , benha university | ||||
| Abstract | ||||
| Potentiometric measurements of L-ascorbic acid's ionization constant as a chelating drug and the stability constants of its Mn2+, Fe3+, Co2+, Cu2+, and Zn2+ metal complexes have been made in an ethanol-water (25% ethanol) and 1.0 molar NaCl medium. The complexes that were generated in solution had stoichiometry values of 1:1 and 2:1 (Asc: M), and the order of stability was Fe3+> Cu2+> Mn2+> Co2+> Zn2+. Different physico-chemical techniques were used to confirm the structures of the solid complexes where a satisfactory agreement between the proposed and theoretical formulae was found. The antibacterial activity toward some Gram positive, Gram negative and fungi was studied taking Ciprofloxacin and Ampicillin as standards. The outcomes show that the metal complexes have a marginally higher level of activity than ascorbic acid in its free form. The DMOL3 tool, designed for wide-scale density function theory (DFT), was used to calculate a few quantum chemical and energetic characteristics of the free drug and its metal complexes. | ||||
| Keywords | ||||
| : L-Ascorbic acid; Potentiometric studies; metal complexes; biological activity; Molecular Modelling | ||||
|
Statistics Article View: 105 PDF Download: 85 |
||||
