Diagnostic Value Of Matrix Metalloproteinase-2 In Children With Refractory Epilepsy | ||||
| Zagazig University Medical Journal | ||||
| Article 6, Volume 31, Issue 2, February 2025, Page 601-612 PDF (938.87 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.330325.3657 | ||||
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| Authors | ||||
Mohamed Ali Abdou Mohamed1; Doaa M. Abdelmonem 2; Asmaa Farag Mohammed Elghareeb  1; Mohammed Ragab Abdellatif3
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| 1Pediatrics Department, Faculty of Medicine, Zagazig University | ||||
| 2Clinical pathology Department, Faculty of Medicine, Zagazig University | ||||
| 3Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Epilepsy is a common neurological condition that causes disruptions in the brain's electrical activity for a number of reasons. Resistant epilepsy is an uncontrollable seizures in spite of two well-toierated, suitably chosen antiepileptic medications (AEDs) given either in combination or as monotherapies. This is the first investigation at Zagazig University Hospitals to find out if refractory epilepsy and Matrix Metalloproteinase-2 are related. The purpose of this study is to evaluate the diagnostic utility of Matrix Metalloproteinase-2 in children receiving treatment at Zagazig University Hospitals for refractory epilepsy. Methods: Forty three children with refractory epilepsy and Forty three healthy children were examined for Matrix Metalloproteinase-2 by Enzyme Linked Immunosorbent Assay (ELISA). Results: The mean MMP-2 concentration exhibited a substantial decrease in the patient group compared to the control group, with a highly significant p-value of <0.001. Conclusion: This study supports that MMP-2 could play a crucial role in timely and precise clinical interventions for children with refractory epilepsy. | ||||
| Keywords | ||||
| Matrix Metalloproteinase-2; Children; Refractory Epilepsy | ||||
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