Effect of duloxetine hydrochloride on the testes of albino rat offspring and possible protective effect of L-carnitine (histological study) | ||
| Journal of Recent Advances in Medicine | ||
| Volume 5, Issue 2, July 2024, Pages 96-110 PDF (4.16 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jram.2024.226611.1229 | ||
| Authors | ||
| Samia A. Ismael* 1; Samir A. Maleek1; Amany M. Abo-Ouf2 | ||
| 1Anatomy and Embryology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||
| 2Anatomy and Embryology, Basic Medical Science Department, College of Medicine, Prince Sattam Bin AbdulAziz University, Al- kharj, Kingdom of Saudi Arabia. | ||
| Abstract | ||
| Background: Duloxetine was a widely used antidepressant approved in 2004 with indications for use in the treatment of major depressive disorder, diabetic neuropathy, fibromyalgia, and generalized anxiety disorder. It induced toxic effects on male reproductive system. L-carnitine improved different parameters of oxidative stress. Objective: to explore the impact of duloxetine hydrochloride treatment and the protective effects of L-carnitine on the histological structure of the testes of male albino rats born to treated mothers. Methodology: In this study, 100 offspring out of 25 adult female albino rats were utilized. Rat females were divided equally into 5 groups as the following: first control group (CA), second control group (CB), L-carnitine group (group L) duloxetine hydrochloride treated group (D), and combined duloxetine hydrochloride and L-carnitine treated group (DL). Throughout their pregnancy and for two weeks following birth, each female in the corresponding groups were given daily oral doses of 0.96ml, 2.06ml of purified water, 36mg L-Carnitine, 1.44 mg of duloxetine hydrochloride and combined 1.44 mg of duloxetine hydrochloride with 36 mg of L-carnitine once daily. At two weeks of age, samples were collected from each group for morphometric, light and electron microscopic analyses. Results: Studies using morphometric analysis, light and electron microscopy demonstrated a variety of degeneration, necrosis, inflammation, and fibrosis. However, L-carnitine mitigated most of the adverse effects. Conclusion: Duloxetine hydrochloride induced various deleterious changes in the testes. These changes were improved to a large extent by L-carnitine. | ||
| Keywords | ||
| Duloxetine hydrochloride; L-Carnitine; rat; testes | ||
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