Epidemiological and Clinical Insights into Pancreaticobiliary Malignancies: An Egyptian Tertiary Centre Study | ||||
| International Journal of Medical Arts | ||||
| Article 5, Volume 6, Issue 11, November 2024, Page 5062-5067 PDF (786.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2024.322815.2040 | ||||
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| Authors | ||||
Omkolsoum Alhaddad1; Maha Elsabaawy1; Mohamed Akl1; Sameh Abu Qoura2; Yehia Fayed3; Mohamed Saad  4
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| 1Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Menoufia, Egypt | ||||
| 2Diagnostic and interventional medical imaging Department, National liver institute, Menoufia University | ||||
| 3Pancreaticobiliary Surgery Department, National Liver Institute, Menoufia University, Menoufia, Egypt | ||||
| 4Department of Hepatology and Gastroenterology, Shebeen Elkoom Teaching Hospital, Menoufia, Egypt | ||||
| Abstract | ||||
| Background: Pancreatic cancer and cholangiocarcinoma rank as exceptionally lethal cancers, typically diagnosed at advanced stages, leading to poor prognoses. Aim of the work: This study aimed to investigate the clinical, epidemiological, laboratory, and diagnostic properties of pancreatic & biliary tract cancers in an Egyptian cohort. Methods: This retrospective, observational study involved a cohort of 600 studied cases diagnosed with pancreatic or biliary tract cancers in a tertiary referral center. Comprehensive data were collected, including demographics, clinical presentations, laboratory investigations, imaging studies, tumor characteristics, and different therapeutic modalities. Results: The mean age of the cases was 59 ± 9 years, with male predominance (67.3%) and a mean body mass index (kg/m²) of 24.5 ± 4.7. Pancreatic cancer (PC) distribution prevailed in the head (43.3%), 19% in the body, 12% in the pancreatic tail, and 22% in cholangiocarcinoma. A significant elevation in serum CA19-9 levels was observed in patients with metastatic tumors compared to those without metastasis (median levels: 656.20 vs. 130.10 U/mL, p < 0.01). Multivariate analysis revealed that older age (OR: 1.05, 95% CI: 1.01–1.09, p < 0.01), positive family history (OR: 2.47, 95% CI: 1.89–3.41, p = 0.04), and elevated serum CA19-9 levels (OR: 1.56, 95% CI: 1.21–2.46, p = 0.03) were significant predictors of advanced disease and poorer prognosis. Conclusion: These findings emphasize the prognostic value of serum CA19-9 levels in assessing the severity of pancreatic & biliary tract cancers. Elevated CA19-9 levels are related to advanced disease & worse overall survival, highlighting the need for early detection and targeted therapeutic strategies to improve studied case results. | ||||
| Keywords | ||||
| Pancreaticobiliary Malignancies; Pancreatic Cancer; Cholangiocarcinoma; Gallbladder Cancer; Epidemiology; Egypt | ||||
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