A Study on Pulmonary Pressure and Serum Ferritin in β-Thalassemic Children | ||
| Journal of Current Medical Research and Practice | ||
| Article 12, Volume 9, Issue 4, October 2024, Pages 113-120 PDF (681.15 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcmrp.2024.392424 | ||
| Authors | ||
| Mostafa Embaby* ; Amr M. Khalifa; Nagwa A. Mohamed | ||
| Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| Abstract | ||
| Background: Among the sequelae associated with a diagnosis of β-thalassemia, pulmonary arterial hypertension remains a concern in patients with β-thalassemia major. Objectives: To evaluate the pulmonary pressure and systolic left ventricular function and detect their relationship with the iron status in β-thalassemic patients. Patients and Methods: A cross-section study on 50 β-thalassemia major children > 5 years old diagnosed by CBC and hemoglobin electrophoresis and on regular blood transfusion/1-2 months was done. The patients were studied by echocardiography regarding their pulmonary pressure level measurement and left ventricular systolic function estimation (FS%). Serum ferritin level was also measured. Results: β-thalassemic children developed systolic and, to a lesser extent, diastolic pulmonary hypertension (36% and 4% respectively). There was a significant positive correlation between serum ferritin level and systolic and diastolic pulmonary pressure. A left ventricular systolic dysfunction was detected in 18% of patients. However, there was no correlation between serum ferritin level and left ventricular systolic dysfunction. Conclusion: Pulmonary hypertension and not the left ventricular systolic dysfunction was related to the serum ferritin level in β-thalassemic children. | ||
| Keywords | ||
| β thalassemia; Pulmonary pressure; Serum ferritin | ||
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