Possible Protective Effect of Ascorbic Acid on the Histopathological Changes of Acrylamide on Jejunum of Adult Male Albino Rats | ||
| Sohag Medical Journal | ||
| Article 8, Volume 21, Issue 2, July 2017, Pages 69-73 PDF (133.29 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2017.39250 | ||
| Authors | ||
| Doha Mohammed; Eman Nor _Eldin; Asmahan Khalifa | ||
| Abstract | ||
| Introduction: Acrylamide (ACR) is a water soluble vinyl monomer that has multiple chemical and industrial applications. Several studies were used with liver, kidney, brain, erythrocyte and proved that (ACR) increase glutathione-s-transferase and causing oxidative stress. Jejunum is the most sensitive part of the intestine, and most of the absorption process occurred in it. Ascorbic acid is natural antioxidant that prevents the increased production of free radicals induced by oxidative damage to various cellular components. Aim of the work: to study the effect of ACR on the jejunum of adult male albino rats and to evaluate the possible role of ascorbic acid as a protective agent. Material and methods: A thirty albino rats were divided into 3 groups: Group Ι: were served as untreated control group. Group IIa received ACR 30 ml\kg b.w orally dailly for 28days Group IIb: received both ACR 30 ml\kg b.w orally simultaneously with ascorbic acid 400ml \kg.b.w intraperitoneally daily for 28 day. Results Exposure to ACR led to histological changes in Group IIa in the form of widening and shortening of villi compared to control group sections. There was inflammatory cell infiltration in the lamina propria, Group IIb showed an improvement in comparison with a groupIIa. This improvement include restoration of villous shape and length, less inflammatory cells infiltration Conclusion: ACR led to histopathological changes in jejunum. These changes attenuated by simultaneous administration of ascorbic acid with ACR. | ||
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1- Dobrowolski P; Huet P; Karlsson P; Eriksson S ;Tomaszewska E; Gawron A and Pierzynowski SG.(2012): Potato fiber protects the small intestinal wall against the toxic influence of acrylamide. Nutrition;28:428-35.
2-Doerge D R; Young J F; McDaniel L P; Twaddle N C and Churchwell, M. I. (2005). Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice. Toxicology and Applied Pharmacology; 202, 258–267.
3-Drake R L; Mitchelle A W M and Vogl W. A. (2007): small intestinal, Gray's anatomy for students 1st edition; 4:265-303 Churchill Livingstone Elsevier.
4-EL-Kenawy A E; Osman H E and Daghestani M H; 2013. The effect of vitamin C administration on monosodium glutamate induced liver injury: An experimental study. Exper. Toxicol. Pathol ; 65: 513-521.
5-El-Mottaleb E M A and Rashed A Y M.(2008): Some studies on acrylamide intoxication in male Albino rats. Egypt J Comp Path Clin Path.;21:222-45
6-Hammad A Y; Osman M E and Abdelgadir W S. (2013): Histopathological assessment and hematotoxicity of dietary acrylamide on Wistar rats. International Journal of Life Sciences ;7, 21– 25.
7-Lee D H and Jacobs D R Jr.(2005):Association between serum gamma-glutamyltransferase and C-reactive protein. Atherosclerosis ; 178: 327–330.
8-Mansour M K; Ibrahim E M; El-Kholy M M and El-Madawy S A. (2008): Antioxidant and histopathological effect of catechin and neem leaves extract in acrylamide toxicity of rats. Egypt J Comp and Clinic Pathol. ;21:290–313.
9-Naruszewicz M; Zapolska-Downar D,;Kosmider A;Norwicka G; Kozlowska-Wojciechowska M; Vikström AS andTo¨rnqvist M(2009): Chronic intake of potato chips in humans increases the production of reactive oxygen radicals by leukocytes and increases plasma C-reactive protein: a pilot study. Am J Clin Nutr. ;89:773–777.
10- Nayanatara A K; Vinodini N A; Ahemed B; Ramaswamy C R; Shabarianth G and Ramesh Bhat M. (2008): Role of ascorbic acid in monosodium glutamate mediated effect on testicular weight, sperm morphology and sperm count, in rat testis. Journal of Chinese Clinical Medicine; 3:1
11-Tomaszewske E; Dobrowolski P; Puzio I; Prost L; Kurlak P; Sawczuk P; Badzian B; Stasiak M H and Kostro K.(2014): Acrylamide-Induced Prenatal Programming of intestine structure in guinea pig. Journal of physiology and pharmacology; 65:107-115.
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