Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration
El Moshy, S., Rady, D., Radwan, I., Abbass, M., El-Rashidy, A., Sadek, K., Ahmed, G., Abouauf, E., AbuBakr, N., Wadan, A., Dörfer, C., Fawzy, K. (2024). Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration. EKB Journal Management System, 6(4), 889-917. doi: 10.21608/adjc.2024.299756.1575
Sara El Moshy; Dina Rady; Israa Ahmed Radwan; Marwa MS Abbass; Aiah A. El-Rashidy; Khadiga M. Sadek; Geraldine Mohamed Ahmed; Eman Ali Abouauf; nermeen Mohamed AbuBakr; Al-Hassan Soliman Wadan; Christof E. Dörfer; Karim Fawzy. "Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration". EKB Journal Management System, 6, 4, 2024, 889-917. doi: 10.21608/adjc.2024.299756.1575
El Moshy, S., Rady, D., Radwan, I., Abbass, M., El-Rashidy, A., Sadek, K., Ahmed, G., Abouauf, E., AbuBakr, N., Wadan, A., Dörfer, C., Fawzy, K. (2024). 'Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration', EKB Journal Management System, 6(4), pp. 889-917. doi: 10.21608/adjc.2024.299756.1575
El Moshy, S., Rady, D., Radwan, I., Abbass, M., El-Rashidy, A., Sadek, K., Ahmed, G., Abouauf, E., AbuBakr, N., Wadan, A., Dörfer, C., Fawzy, K. Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration. EKB Journal Management System, 2024; 6(4): 889-917. doi: 10.21608/adjc.2024.299756.1575

Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration

Advanced Dental Journal
Volume 6, Issue 4, October 2024, Page 889-917  XML PDF (1.02 MB)
Document Type: Review Article
DOI: 10.21608/adjc.2024.299756.1575
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Authors
Sara El Moshyorcid 1; Dina Rady2; Israa Ahmed Radwanorcid 2; Marwa MS Abbass email orcid 2; Aiah A. El-Rashidyorcid 3; Khadiga M. Sadek4; Geraldine Mohamed Ahmedorcid 5; Eman Ali Abouauforcid 6; nermeen Mohamed AbuBakrorcid 7; Al-Hassan Soliman Wadan8; Christof E. Dörfer9; Karim Fawzyorcid 10
1Department of Oral Biology, Faculty of Dentistry, Cairo University, Egypt
2Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt
3Faculty of Dentistry, Cairo University
4Biomaterials Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
5Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt
6conservative Dentistry, Faculty of Dentistry Cairo University
7Oral Biology Department, Faculty of Dentistry, Cairo University.
8Sinai University, Faculty of Dentistry, Arish Branch, North Sinai, Egypt
9Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany
10Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt
Abstract
Dental mesenchymal stem cells (MSCs) have emerged as a promising therapeutic avenue for tissue regeneration in regenerative medicine. While cellular transplantation of MSCs has shown potential for achieving functional tissue regeneration, several clinical challenges hinder its implementation. An alternative approach, harnessing the secretome of MSCs, has gained attention as a cell-free therapeutic strategy. The secretome encompasses the bioactive molecules released by MSCs, which have been shown to exert profound effects on tissue regeneration. This review comprehensively analyzes the dental MSCs secretome, understanding the potential of the MSCs secretome, addressing the obstacles associated with its utilization, and its potential as a valuable resource for regenerative therapies. In summary, the secretome of dental MSCs holds great promise as a cell-free therapeutic strategy for tissue regeneration. This review highlights the importance of further research and standardization efforts to fully exploit the therapeutic potential of the MSCs secretome and realize its clinical translation in regenerative medicine.
Keywords
Dental mesenchymal stem cells; Secretome; cell-free therapy; tissue regeneration
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