Assessment of Toll-Like Receptor 1 in Type1 Diabetic Children: In Relation to Glycemic Control | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 7, July 2025, Page 515-525 PDF (673.43 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.326585.10592 | ||||
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| Authors | ||||
Hanaa R. Abdallah1; Marwa A. Mahmoud2; Rehab S.I. Moustafa3; Ahmed Adel3; Mina Wassef Girgiss4; Ahmed Helal Elsayed5; Hanan Hanna   6
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| 1Biological Anthropology Department, Medical Researches and Clinical Studies Institute– National Research Centre Cairo, Egypt. | ||||
| 2Medical Biochemistry Department, Medical Research and Clinical Studies National Research Centre, Doki, Giza, Egypt. | ||||
| 3Child health department, medical research and Clinical Studies, National Research Centre, Cairo, Egypt. | ||||
| 4Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt. | ||||
| 5Department of Pediatrics, Faculty of Medicine for boys Al-Azhar University, Cairo, Egypt. | ||||
| 6Clinical Pathology, Faculty of Medicine – Delta University for Science and Technology, Gamasa, Egypt. | ||||
| Abstract | ||||
| Abstract Background: Diabetic children and adolescents with type 1 diabetes are susceptible to infections and complications due to potential immune dysfunction. Toll-like receptor 1 (TLR1) is a mediator of the innate immune response and insulin-like growth factor 1 (IGF-1), which play crucial roles in immunity and growth, respectively. Impaired glycemic control is associated with elevated TLR1 and Reduced IGF-1 in children with type 1 diabetes Methods: A cross-sectional study involving 140 children, aged 6-18 years, was conducted, including three groups: (group 1) healthy controls (HbA1c < 6%). We categorized diabetic patients into: (group 2) good HbA1c level < 8%, and (group 3) poor glycemic diabetic patients HbA1c level > 9%. Clinical data, anthropometry, glycated hemoglobin (HbA1c), insulin growth factor-1, and serum TLR1 levels were assessed. Results: Children with poor glycemic control with HbA1c > 9% had statistically significant higher TLR-1 levels, BMI Z scores, waist/hip, waist/height, and skin fold thicknesses compared to those with HbA1c <8% (P < 0.05). However, IGF-1 showed a lower level in diabetic patients compared to the control group. Conclusions: Our findings suggest that poor glycemic control in children with type 1 diabetes and increased adiposity is correlated with increased levels of TLR1 and IGF-1, potentially contributing to a heightened inflammatory state and increased risk of complications. | ||||
| Keywords | ||||
| Type 1 diabetes mellitus (T1DM); Toll-like receptor 1 (TLR1) and insulin-like growth factor 1 (IGF-1); Skin fold thickness | ||||
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