Synthesis, characterization and biological activity of cadmium (II) complex of hydrazone moiety | ||||
| Research Journal of Applied Biotechnology | ||||
| Article 2, Volume 10, Issue 2, December 2024, Page 12-23 PDF (677.35 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/rjab.2024.312873.1055 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Samar A. Aly  1; Safaa Hassan2; Safinaz A. Farfour3; Ehab M. Abdalla 4; Tasneem Abdel-hady5
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| 1Genetic Engineering and Biotechnology Research Institute | ||||
| 2Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt | ||||
| 3Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City 32958, Egypt | ||||
| 4Chemistry Department, Faculty of Science, New Valley University, Alkharga 72511, Egypt. | ||||
| 5Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City 32958, Egypt. | ||||
| Abstract | ||||
| With the aid of hydrazone moiety, a novel Cd(II) chelate with 2-[(4-methylphenyl)amino]-N'-[(Z)-thiophen-2-ylmethylidene]acetohydrazide (H2L) was created and reported. These novel chemicals' structural makeup was clarified through the utilization of spectroscopic and analytical methods. The chelates were molded with a molar ratio of 1:1 M:L and the formula [Cd(H2L)Cl2]. Cd(II) complex of the biological activity ligand is investigated. Theoretical measurements supported the proposed generic formula for the [Cd(H2L)Cl2] complex. The compound's anticancer and antibacterial properties were evaluated using cisplatin, gentamicin, and ampicillin as standards. It was found that the Cd 2+ complex was more effective against two cancer cell lines and several bacterial strains than it was against ligand. The results showed that the compound's activities were: Cd(II) complex > H2L, with Cd(II) complex exhibiting the maximum activity. By examining the binding between the complex and Penicillin-binding protein PBP, which is primarily thought of as the production of the cell wall through its transglycosylation and transpeptidation, a molecular docking study was carried out to support the microbial inhibition growth. | ||||
| Keywords | ||||
| Complex; Antibacterial; Anticancer; Molecular Docking | ||||
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