Relationship between Sperm DNA Fragmentation and Interleukin 17 in Patients with Leukocytospermia | ||||
| Journal of Bioscience and Applied Research | ||||
| Volume 10, Issue 4, November 2024, Page 809-815 PDF (494.2 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2024.392991 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hayder L F AL-Msaid   1; Hydar Muhsin Khalfa1; Ammar Adil Rashid1; Nawras Noori Mohammad Hussain2
| ||||
| 1Department of Biology, College of Sciences, University of Kufa, Najaf, Iraq | ||||
| 2Al -mustaqbal University. College of medical and health techniques and science, Department of Medical Laboratory Techniques, Iraq | ||||
| Abstract | ||||
| Over the past few decades, fertility treatments have witnessed a remarkable development, inflammation in the sexual glands attached to some patients in addition to immune disorders in patients, which are among the main causes of delayed pregnancy. A hidden molecular cause of infertility is sperm DNA fragmentation which can be attributed to many cases of infertility. This study aims to correlate the relationship between sperm DNA fragmentation and interleukin 17A in patients who suffer from leukocytospermia. Samples were collected from patients with Leukocytospermia (n=30) and healthy individuals (n=18). The present study showed a significant increase in Interleukin 17A levels in Leukocytospermia patients compared with the control group (mean± Std. Error 356.5± 6.14 & 141.37± 1.32) also significant sperm DNA Fragmentation level was noticeably decreased in Leukocytospermia compare with control group (mean± Std. Error 30.85±1.17 & 79.16±3.24 Consecutive). The results show a negative correlation between the Interleukin 17A level and sperm DNA Fragmentation level in Leukocytospermia patients. The study concluded the inflammation of patients affects an increase in the percentage of abnormal sperm chromatin that was assessed using the aniline blue dye. An increase in the level of pro-inflammatory such as interleukin 17 plays a critical role in the pathogenesis and inflammation, while a negative correlation between (Interleukin 17A level and the sperm DNA Fragmentation level in Leukocytospermia patients. | ||||
| Keywords | ||||
| Sperm DNA Fragmentation; IL17; Leukocytospermia | ||||
|
Statistics Article View: 167 PDF Download: 131 |
||||
