Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat
Tousson, E., Dora, M., Beltagy, D., Abdel bari, H., Alankooshi, A., Ahmed, A. (2024). Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat. EKB Journal Management System, 10(4), 866-878. doi: 10.21608/jbaar.2024.393267
Ehab Tousson; Mona A. Dora; Doha Mohammad Beltagy; Hamed Muhammad Abdel bari; Azhar Azher Alankooshi; Amira Saber Ahmed. "Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat". EKB Journal Management System, 10, 4, 2024, 866-878. doi: 10.21608/jbaar.2024.393267
Tousson, E., Dora, M., Beltagy, D., Abdel bari, H., Alankooshi, A., Ahmed, A. (2024). 'Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat', EKB Journal Management System, 10(4), pp. 866-878. doi: 10.21608/jbaar.2024.393267
Tousson, E., Dora, M., Beltagy, D., Abdel bari, H., Alankooshi, A., Ahmed, A. Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat. EKB Journal Management System, 2024; 10(4): 866-878. doi: 10.21608/jbaar.2024.393267

Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat

Journal of Bioscience and Applied Research
Volume 10, Issue 4, November 2024, Pages 866-878    PDF (1.82 M)
Document Type: Original Article
DOI: 10.21608/jbaar.2024.393267
Authors
Ehab Tousson* 1; Mona A. Dora2; Doha Mohammad Beltagy3; Hamed Muhammad Abdel bari2; Azhar Azher Alankooshi4; Amira Saber Ahmed5
1Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt
2Department of Chemistry, Faculty of Science, Menoufia University, Egypt
3Department of Chemistry, Faculty of Science, Damanhour University, Egypt
4Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt/ Department of Human Physiology, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Iraq
5Hormones Department, Medical Research and Clinical Studies Institute, NationalResearch Centre, Giza, Egypt
Abstract
Metal nanoparticles (NPs) that are considered to be copper oxide nanoparticles (CuONPs) have received more attention in recent years and have a significant impact on everyday life due to their large area of influence. Therefore, the current study sought to explore the therapeutic effects of curcumin (Cur) and/or curcumin nanoparticles (CurNPS) concerning DNA damage, oxidative stress, apoptosis, and inflammation in the kidneys of rats. 60 male rats in the maturity stage were divided into 6 groups (G1, control; G2, Cur; G3, Cur NPS; G4, CuONPs; G5, CuONPs+Cur; G6, CuONPs+CurNPS). Current results revealed a significant elevation in serum levels of creatinine, urea, potassium ions, chloride ions, kidney MDA, DNA damage, kidney injury, PCNA, and P53 expressions, and a significant decline in sodium ions, and calcium ions when compared to control. Interestingly, treatment of CuONPs with Cur or CurNPS revealed modulation in these parameters compared to the CuONPs group with the most favorable results observed in CuONPs+CurNPs.
Keywords
Copper oxide nanoparticles; Curcumin nanoparticles; kidney; oxidative stress; PCNA& P53
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