Kidney injury molecule-1(KIM-1) as a diagnostic and prognostic biomarker for acute kidney injury in septic patients.
Mohamed, M., Mahmoud, O., Al-Maraghi, S., Abogabal, K., El-Kholy, M. (2024). Kidney injury molecule-1(KIM-1) as a diagnostic and prognostic biomarker for acute kidney injury in septic patients.. EKB Journal Management System, 5(4), 236-249. doi: 10.21608/ejmr.2024.283655.1606
M. Sayed Mohamed; Omar M. Mahmoud; Sameh K. Al-Maraghi; Khadiga M. Abogabal; Mohamed B. El-Kholy. "Kidney injury molecule-1(KIM-1) as a diagnostic and prognostic biomarker for acute kidney injury in septic patients.". EKB Journal Management System, 5, 4, 2024, 236-249. doi: 10.21608/ejmr.2024.283655.1606
Mohamed, M., Mahmoud, O., Al-Maraghi, S., Abogabal, K., El-Kholy, M. (2024). 'Kidney injury molecule-1(KIM-1) as a diagnostic and prognostic biomarker for acute kidney injury in septic patients.', EKB Journal Management System, 5(4), pp. 236-249. doi: 10.21608/ejmr.2024.283655.1606
Mohamed, M., Mahmoud, O., Al-Maraghi, S., Abogabal, K., El-Kholy, M. Kidney injury molecule-1(KIM-1) as a diagnostic and prognostic biomarker for acute kidney injury in septic patients.. EKB Journal Management System, 2024; 5(4): 236-249. doi: 10.21608/ejmr.2024.283655.1606

Kidney injury molecule-1(KIM-1) as a diagnostic and prognostic biomarker for acute kidney injury in septic patients.

Egyptian Journal of Medical Research
Volume 5, Issue 4, October 2024, Pages 236-249    PDF (680.94 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.283655.1606
Authors
M. Sayed Mohamed* 1; Omar M. Mahmoud1; Sameh K. Al-Maraghi1; Khadiga M. Abogabal2; Mohamed B. El-Kholy1
1Critical care department, Faculty of Medicine, Beni Suef University, Egypt.
2Clinical pathology department, Faculty of Medicine, Beni Suef University, Egypt.
Abstract
Background: acute kidney injury (AKI) is a common devastating problem in patients complaining of sepsis and septic shock. the deficiency of a slandered consensus definition of AKI make its incidence varies markedly ,the increased incidence of mortality and morbidity in septic patients developing AKI necessitates studying specific biomarkers to diagnosis and assess prognosis and outcome is necessary.  The proximal tubule is the source of kidney injury molecule 1 (KIM-1) which is expressed in case of acute ischaemia. like, acute tubular necrosis. even before serum creatinine rise KIM-1 in urine may be detected after exposure to a many of nephrotoxic agents. Objective: Our aim was to validate that the kidney injury molecule -1 (KIM–1) in urine as a diagnostic and prognostic biomarker in evaluation of preclinical kidney toxicity to facilitate early diagnosis and management of AKI.  Methods: 20 critically ill patients diagnosed with sepsis were included in our study, ten healthy volunteers as a control group. The study was done on patients admitted to the critical care department in Beni-Suef university in the period from February to December 2023. Urine samples were collected from the studied patients on admission day (day 0), 2nd day of admission (day 2) and 5th day of admission (day 5), and only once in control group to correlate between KIM 1 levels in patients and control group and to correlate with development of AKI . Results: Our study showed that KIM-1 and creatinine on admission were not significantly correlated in the study group ; (R: 0.123) and p value 0.6. On the other hand KIM-1 on admission and creatinine on day 2 were positively correlated in the study group ; (R: 0.9) with highly significant p value ( 0.0001) and KIM-1 on admission and creatinine on day 5 were positively correlated in the study group ; (R: 0.9) with highly significant p value ( 0.0001 ), KIM-1 on admission at 954pg/ml predicted mortality of the study group with the area under the receiver operating characteristic curve (AUC) 0.96 (sensitivity 87.5% & specificity 84.3 %)with significant p value (0.001). Conclusion: From our study we could suggest that urinary KIM 1 level can be utilized as a good diagnostic and prognostic biomarker for detection of AKI in sepsis
Keywords
KIM-1; AKI; Sepsis
References
  1. Pickkers P, Darmon M, Hoste E, et al. Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Intensive Care Med. 2021;47(8):835-850.
  2. De Mendonca A, Vincent JL, Suter PM, Moreno R, Dearden NM, Antonelli M, Takala J, Sprung C, Cantraine F: Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med 2000; 26:915-921.
  3. Anandkumar DG, Dheerendra PC, Vellakampadi D, Ramanathan G. Kidney injury molecule-1; is it a predictive marker for renal diseases?. Journal of Nephropharmacology. 2023 Mar 18;12(2):e10572-.
  4. Brivet FG et al.: Acute renal failure in intensive care units--causes, outcome, and prognostic factors of hospital mortality; a prospective, multicenter study. French Study Group on Acute Renal Failure. Crit Care Med, 1996; 24 (2): P. 192-8.
  5. American College of Chest Physicians: Society of Critical Care Medicine Consensus Conference. Crit Care Med 1992; 20:864–74©.
  6. Bellomo R et al.: Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care, 2004; 8(4): P. R204-12.
  7. Mehta RL et al.: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care, 2007; 11(2): P. R31.
  8. Nfor TK, Walsh TS, Prescott RJ. The impact of organ failures and their relationship with outcome in intensive care: Analysis of a prospective multicentre database of adult admissions. Anaesthesia. 2006;61:731–8.
  9. Park MR, Jeon K, Song JU, Lim SY, Park SY, Lee JE, et al. Outcomes in critically ill patients with hematologic malignancies who received renal replacement therapy for acute kidney injury in an intensive care unit. J Crit Care. 2011;26:107.e1–6.
  10. Kenney EM, Rozanski EA, Rush JE, deLaforcade-Buress AM, Berg JR, Silverstein DC, et al. Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003-2007) J Am Vet Med Assoc. 2010;236:83–7.
  11. Takeshi Umegaki, Hiroshi Ikai, and Yuichi Imanaka,: The impact of acute organ dysfunction on patients' mortality with severe sepsis, J Anaesthesiol Clin Pharmacol. 2011 Apr-Jun; 27(2): 180–184.
  12. Thijs A, Thijs B: Pathogenesis of acute renal failure during sepsis. Kidney Int 53[Suppl 66]: 1998, S34-S37.
  13. Levy EM, Viscoli CM, Horwitz RI: The effect of acute renal failure on mortality. A cohort analysis JAMA 1996; 1489–1494.
  14. Brivet FG et al.: Acute renal failure in intensive care units--causes, outcome, and prognostic factors of hospital mortality; a prospective, multicenter study. French Study Group on Acute Renal Failure. Crit Care Med, 1996; 24 (2): P. 192-8.
  15. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury following cardiac surgery. Lancet. 2005;365:1231–8.
  16. Herget-Rosenthal S, Marggraf G, Hüsing J, Göring F, Pietruck F, Janssen O, et al. Early detection of acute renal failure by serum cystatin C. Kidney Int. 2004;66:1115–22.
  17. Wagener G, Jan M, Kim M, Mori K, Barasch JM, Sladen RN, et al. Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology. 2006;105:485–91.
  18. Parikh CR, Jani A, Melnikov VY, Faubel S, Edelstein CL. Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis. 2004;43:405–14.
  19. Liangos O, Han WK, Wald R. Urinary kidney injury molecule-1 level is an early and sensitive marker of acute kidney injury following cardiopulmonary bypass. J Am Soc Nephrol. 2006;17:403A.
  20. Van Timmeran MM, Van den Heuvel Mc, Bailly V, Bakker SJ, van Goor H,Stegeman CA. Tubular kidney injury molecule -1 (KIM -1) in human renal disease. J. pathol. 2007 ; 212:209-217.
  21. Gamal F. EL Naggar , Hesham A. El Srogy, Sameh M. Fathy: Kidney Injury Molecule -1 (KIM-1): an early novel biomarker for Acute Kidney Injury (AKI) in critically – ill Patients, Life Science Journal 2012;9(4).
  22. Han WK, Bailly V, Abichandani R et al. Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 2002; 62: 237–244.
  23. Han WK, Waikar SS, Johnson AM et al. Urinary biomarkers for detection of acute kidney injury. Kidney Int 2007 (in press).
  24. Metzger J, Kirsch T, Schiffer E, et al Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury. Kidney Int 2010;78:1252-1262.
  25. Koyner JL, Vaidya VS, Bennett MR, et al Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol 2010;5:2154-2165
  26. Liangos O, Tighiouart H, Perianayagam MC, et al Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers 2009;14:423-431.
  27. Liang XL, Liu SX, Chen YH, et al Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study. Biomarkers 2010;15:332-339.
  28. SG Coca, R Yalavarthy , J Concato and CR Parikh: Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review, Kidney International (2008) 73, 1008–1016
  29. FDA News. (2008): FDA, European medicines agency to consider additional test results when assessing new drug safety collaborative effort by FDA and EMEA expected to yield additional safety data. FDA News 2008; 12 June.
  30. Van Timmeren MM, Vaidya VS, Van Ree RM et al. (2007): High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation; 84:1625–1630.
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