Synthesis, Molecular Docking and Anticancer Activity of New Pyridyl-1,2,4-Triazole-Thioglycosides and Their Pyridyl-[1,2,4]triazolo[1,5-a]pyridine-Glycoside Analogues | ||
| Egyptian Journal of Chemistry | ||
| Volume 67, Issue 13, December 2024, Pages 1251-1260 PDF (1.17 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.328404.10629 | ||
| Authors | ||
| Dania Alweet1; Mohamed N. El-Bayaa1, 2; Sobhi M. Gomha* 3; Fahad M. Almendrej1; Eman S. Nossier4; Ahad El-Enazy1; Wael A. El-Sayed1 | ||
| 1Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia | ||
| 2Department of Photochemistry, National Research Centre, Cairo 12622, Egypt. | ||
| 3Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia | ||
| 4Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. | ||
| Abstract | ||
| Cancer remains a main threat for human life and requires intensive research for discovering and developing treatment strategies. The design and synthesis of novel functionalized and hybrid structures as candidates for anticancer activity investigation have been proven in the literature as an efficient approach for providing a variety of compounds. In the current work, new compounds of hybrid structures incorporating aryl- or heteroarylpyridine, 1,2,4-triazole, glycosyl moieties have been prepared via a stepwise pathway starting from simple available starting compounds. The anticancer activity against MCf-7, PC3 and A549 human cancer cell lines revealed that substituted 1,2,4-triazole-thiol based substituted pyridine structure and the N-glycosyl derivative of the 1,2,4-triazolopyridine compounds exhibited the most potent activities against MCF-7 and A549 cancer cells. Molecular docking into EGFR active site and showed good binding affinities via various modes. | ||
| Keywords | ||
| Pyridine; 1; 2; 4-triazole; glycosides; anticancer activity; molecular docking | ||
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