Comparison between high flow nasal cannula and non-invasive mechanical ventilation in the management of patients with acute respiratory failure: A meta-analysis | ||||
| Benha Medical Journal | ||||
| Article 3, Volume 42, Issue 1, January 2025, Page 23-35 PDF (1.12 MB) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/bmfj.2024.267052.2009 | ||||
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| Authors | ||||
Enas Wageih Mahdy1; Ahmed Mostafa Abd El-Hamid2; Doaa Kamal Ahmed Ibrahim Kotb  3; Emad Fawzy Rizk Ibrahim3
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| 1Assistant Professor of Anesthesia & Intensive Care Faculty of Medicine - Benha University | ||||
| 2Department of anesthesia & intensive care, Faculty of Medicine, Benha University | ||||
| 3Department of Critical Care Medicine, Faculty of Medicine, Benha University | ||||
| Abstract | ||||
| Background: Acute respiratory failure is potentially life threatening. It does not require immediate intubation and the likelihood of a positive result hinges on the doctor's capacity to promptly identify the syndrome and implement suitable actions to aid and recover respiratory system function. Objectives: The research aimed to contrast the use of high-flow nasal cannula and non-invasive mechanical ventilation in treating patients experiencing acute respiratory failure. Study design: A meta-analysis study adhering to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines was conducted. Methods: Online databases (PubMed, Embase, Biomed, and the Cochrane Central Register of Controlled trials) were utilized to detect all published randomized studies that compare the impact of high-flow nasal cannula with non-invasive ventilation in patients dealing with acute respiratory failure. Results: Thirteen trials, encompassing a total of 1284 patients, were incorporated in the study. The risk of bias was minimal. The results revealed no substantial decrease in mortality. There was a significant reduction in length of hospital stay and a significant improvement in comfort score favouring the high flow nasal cannula group. However, there was no significant change in length of ICU stay, intubation rate, PaCO2, PaO2, PaO2/FiO2 ratio, SpO2, MAP and HR. Conclusion: This meta-analysis showed no significance of high flow nasal cannula over non-invasive mechanical ventilation in reducing mortality rates. However, high flow nasal cannula is associated with reduction of length of hospital stay and improvement of comfort score. | ||||
| Keywords | ||||
| Non-invasive mechanical ventilation; High flow nasal cannula; Acute respiratory failure; Meta-analysis; Randomized trials | ||||
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