Harnessing Isosaponarin: A Multifaceted Bioactive and Therapeutic Potential Compound from Nature | ||||
| Biological and Biomedical Journal | ||||
| Volume 3, Issue 2, July 2025, Page 1-12 PDF (857.18 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/bbj.2024.331198.1047 | ||||
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| Authors | ||||
Firdos Kaynat1; Saddam Hussain1; Basim. S. A. Al Sulivany2; Muhammad J Iqbal3; Muhammad Owais4; Paracha N Rizwan5; Rana M. Fazal  6
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| 1Department of Zoology, Faculty of Basic Sciences, University of Agriculture, Dera Ismail Khan, KPK, Pakistan | ||||
| 2Department of Biology, College of Science, University of Zakho, Zakho, 42002, Duhok, Kurdistan Region, Iraq | ||||
| 3Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Punjab, Pakistan. | ||||
| 4Department of Zoology, Emerson University Multan, Punjab, Pakistan | ||||
| 5Department of Chemistry, Faculty of Science, Thal University Bhakkar, Punjab, Pakistan | ||||
| 6Department of Zoology, Ghazi University, Dera Ghazi Khan, Punjab, Pakistan. | ||||
| Abstract | ||||
| Flavonoids represent a class of plant bioactive compounds renowned for their multifaceted health benefits. Among phytochemicals, polyphenols like Isosaponarin, a well-studied flavonoid, are widely distributed across various herbs and plant families, presenting notable antimicrobial and antioxidant properties. Numerous plant species harbour the Isosaponarin compound, each with distinct clinical and traditional applications. Isosaponarin-rich plants exhibit strong antimicrobial and antioxidant properties alongside noteworthy anti-hyaluronidase activity. This flavone glycoside also upregulates the mRNA gene level of type I collagen production, promoting skin health and wound healing. Studies highlight the significant effect of Isosaponarin on collagen synthesis, particularly notable in its derivation from wasabi rhizome extract and its application as a fragrance ingredient. Moreover, the research underscores its diverse biological activities, encompassing antiplatelet, anti-atopic dermatitis, and anti-tumor effects. This review aims to provide a comprehensive account of the botanical and dietary sources of Isosaponarin while delving into pivotal studies elucidating its antimicrobial and antioxidant prowess, role as an anti-hyaluronidase agent, mitigation of oxidative glutamate toxicity, and facilitation of type I collagen synthesis. | ||||
| Keywords | ||||
| Isosaponarin; multifaceted; antimicrobial; antioxidant and anti-hyaluronidase agent | ||||
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