Role of MicroRNA (182) in Differentiation Between Benign and Malignant Pleural Effusion

Allam, Amira Hussein; Omar, Magdy Mohamed; El Noury, Hmasat Abd El Hafez; Rawy, Abeer Mohamed; Anwar, Toqa Ayman; El Sawy, Rehab El Sayed

doi:10.21608/bmfj.2024.331386.2240

	Role of MicroRNA (182) in Differentiation Between Benign and Malignant Pleural Effusion
Benha Medical Journal
Article 7, Volume 42, Issue 4, April 2025, Page 403-418 PDF (1.04 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.331386.2240
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Authors
Amira Hussein Allam ¹; Magdy Mohamed Omar²; Hmasat Abd El Hafez El Noury³; Abeer Mohamed Rawy⁴; Toqa Ayman Anwar ⁵; Rehab El Sayed El Sawy⁴
¹Chest Department, Faculty of Medicine, Benha University
²Pofessor of Chest Diseases, Faculty of Medicine, Benha University
³Assistant Professor of Clinical Pathology, Faculty of Medicine - Benha University
⁴Assistant Professor of Chest Diseases, Faculty of Medicine, Benha University
⁵M.B.B.Ch, Faculty of Medicine, Benha University
Abstract
Background: Differential diagnosis between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains a clinical challenge. Aim: to evaluate the role of microRNA (182) in differentiation between tuberculous (TPE) and malignant pleural effusion (MPE). Methods: This cross-sectional study included 60 patients admitted at the Chest Department, Benha University Hospital. Patients were divided into two groups based on pathology results: Group A (n=45): MPE and Group B: (n=15): TPE. miRNA 182 was measured by qt PCR in both groups and expressed as ΔΔCT and fold change(2-ΔΔCt ) Results: No statistically significant difference between MPE and TPE regarding ΔΔCT and fold change and the level did not differ significantly between malignant types. Adenosine deaminase (ADA) can significantly differentiate between malignant and TB groups (P
Keywords
MicroRNA(182); Differentiation; Benign; Malignant Pleural Effusion


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