Role of MicroRNA (182) in Differentiation Between Benign and Malignant Pleural Effusion | ||
| Benha Medical Journal | ||
| Article 7, Volume 42, Issue 4, April 2025, Pages 403-418 PDF (1.04 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.331386.2240 | ||
| Authors | ||
| Amira Hussein Allam1; Magdy Mohamed Omar2; Hmasat Abd El Hafez El Noury3; Abeer Mohamed Rawy4; Toqa Ayman Anwar* 5; Rehab El Sayed El Sawy4 | ||
| 1Chest Department, Faculty of Medicine, Benha University | ||
| 2Pofessor of Chest Diseases, Faculty of Medicine, Benha University | ||
| 3Assistant Professor of Clinical Pathology, Faculty of Medicine - Benha University | ||
| 4Assistant Professor of Chest Diseases, Faculty of Medicine, Benha University | ||
| 5M.B.B.Ch, Faculty of Medicine, Benha University | ||
| Abstract | ||
| Background: Differential diagnosis between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains a clinical challenge. Aim: to evaluate the role of microRNA (182) in differentiation between tuberculous (TPE) and malignant pleural effusion (MPE). Methods: This cross-sectional study included 60 patients admitted at the Chest Department, Benha University Hospital. Patients were divided into two groups based on pathology results: Group A (n=45): MPE and Group B: (n=15): TPE. miRNA 182 was measured by qt PCR in both groups and expressed as ΔΔCT and fold change(2-ΔΔCt ) Results: No statistically significant difference between MPE and TPE regarding ΔΔCT and fold change and the level did not differ significantly between malignant types. Adenosine deaminase (ADA) can significantly differentiate between malignant and TB groups (P | ||
| Keywords | ||
| MicroRNA(182); Differentiation; Benign; Malignant Pleural Effusion | ||
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