Pyrimidine as a naturally occurring bioactive ring and its importance in different arenas | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 7, July 2025, Pages 71-98 PDF (1.84 M) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2024.299076.9897 | ||
| Authors | ||
| Mosaad Sayed Mohamed1; Samar S. Fatahala2; Rania Helmy Abd El-Hameed3; Mariem El Saeed Mohamed* 1 | ||
| 1Pharmaceutical organic chemistry , faculty of pharmacy , helwan university, cairo,egypt | ||
| 2Pharmaceutical Organic Chemistry Department, Faculty of pharmacy, Helwan University | ||
| 3Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Helwan, Egypt. | ||
| Abstract | ||
| The pyrimidine ring is widely known for its biological activity through history, either by itself or attached to other heterocyclic rings. The importance of pyrimidine is due to its presence in the nucleic acid, in addition to its presence in natural and synthetic drugs. Based on the ring significance, that’s an overview of the recent pyrimidines synthesis, reactions and its different biological activities over the past three years. It was shown that it has a generous contribution to the pharmaceutical industry. Scientists are still working on its derivatives to get promising results in different areas, especially as anticancer agents. | ||
| Keywords | ||
| Pyrimidine; anticancer; synthesis; reactions; biological activity | ||
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